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Analysis of transcriptional changes in the immune system associated with pubertal development in a longitudinal cohort of children with asthma

Author

Listed:
  • Justyna A. Resztak

    (Wayne State University)

  • Jane Choe

    (Wayne State University)

  • Shreya Nirmalan

    (Wayne State University)

  • Julong Wei

    (Wayne State University)

  • Julian Bruinsma

    (Wayne State University)

  • Russell Houpt

    (Wayne State University)

  • Adnan Alazizi

    (Wayne State University)

  • Henriette E. Mair-Meijers

    (Wayne State University)

  • Xiaoquan Wen

    (University of Michigan)

  • Richard B. Slatcher

    (University of Georgia)

  • Samuele Zilioli

    (Wayne State University
    Wayne State University)

  • Roger Pique-Regi

    (Wayne State University
    Wayne State University)

  • Francesca Luca

    (Wayne State University
    Wayne State University
    University of Rome Tor Vergata)

Abstract

Puberty is an important developmental period marked by hormonal, metabolic and immune changes. Puberty also marks a shift in sex differences in susceptibility to asthma. Yet, little is known about the gene expression changes in immune cells that occur during pubertal development. Here we assess pubertal development and leukocyte gene expression in a longitudinal cohort of 251 children with asthma. We identify substantial gene expression changes associated with age and pubertal development. Gene expression changes between pre- and post-menarcheal females suggest a shift from predominantly innate to adaptive immunity. We show that genetic effects on gene expression change dynamically during pubertal development. Gene expression changes during puberty are correlated with gene expression changes associated with asthma and may explain sex differences in prevalence. Our results show that molecular data used to study the genetics of early onset diseases should consider pubertal development as an important factor that modifies the transcriptome.

Suggested Citation

  • Justyna A. Resztak & Jane Choe & Shreya Nirmalan & Julong Wei & Julian Bruinsma & Russell Houpt & Adnan Alazizi & Henriette E. Mair-Meijers & Xiaoquan Wen & Richard B. Slatcher & Samuele Zilioli & Rog, 2023. "Analysis of transcriptional changes in the immune system associated with pubertal development in a longitudinal cohort of children with asthma," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-022-35742-z
    DOI: 10.1038/s41467-022-35742-z
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    References listed on IDEAS

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    1. Felix R. Day & Brendan Bulik-Sullivan & David A. Hinds & Hilary K. Finucane & Joanne M. Murabito & Joyce Y. Tung & Ken K. Ong & John R.B. Perry, 2015. "Shared genetic aetiology of puberty timing between sexes and with health-related outcomes," Nature Communications, Nature, vol. 6(1), pages 1-6, December.
    2. Lara M. Mangravite & Barbara E. Engelhardt & Marisa W. Medina & Joshua D. Smith & Christopher D. Brown & Daniel I. Chasman & Brigham H. Mecham & Bryan Howie & Heejung Shim & Devesh Naidoo & QiPing Fen, 2013. "A statin-dependent QTL for GATM expression is associated with statin-induced myopathy," Nature, Nature, vol. 502(7471), pages 377-380, October.
    3. Cosetta Minelli & Diana A van der Plaat & Bénédicte Leynaert & Raquel Granell & Andre F S Amaral & Miguel Pereira & Osama Mahmoud & James Potts & Nuala A Sheehan & Jack Bowden & John Thompson & Debbie, 2018. "Age at puberty and risk of asthma: A Mendelian randomisation study," PLOS Medicine, Public Library of Science, vol. 15(8), pages 1-14, August.
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