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Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites

Author

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  • Zaiming Tang

    (Center for Autophagy Research, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center
    Biophysics and Structural Biology, University of California
    State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University)

  • Mary Grace Lin

    (Biophysics and Structural Biology, University of California)

  • Timothy Richard Stowe

    (Stanford University)

  • She Chen

    (National Institute of Biological Sciences)

  • Muyuan Zhu

    (State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University)

  • Tim Stearns

    (Stanford University)

  • Brunella Franco

    (Medical Genetics Services, Federico II University, Via Pietro Castellino 111, Naples, Italy
    Telethon Institute of Genetics and Medicine (TIGEM), Via Pietro Castellino 111, Naples, Italy)

  • Qing Zhong

    (Center for Autophagy Research, University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center
    Biophysics and Structural Biology, University of California)

Abstract

The primary cilium is a microtubule-based organelle that functions in sensory and signal transduction; the authors demonstrate here that autophagic degradation of the oral-facial-digital syndrome 1 (OFD1) protein at centriolar satellites promotes primary cilium biogenesis, and that autophagy modulation might provide a novel means of ciliopathy treatment.

Suggested Citation

  • Zaiming Tang & Mary Grace Lin & Timothy Richard Stowe & She Chen & Muyuan Zhu & Tim Stearns & Brunella Franco & Qing Zhong, 2013. "Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites," Nature, Nature, vol. 502(7470), pages 254-257, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7470:d:10.1038_nature12606
    DOI: 10.1038/nature12606
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    Cited by:

    1. Aurore Claude-Taupin & Pierre Isnard & Alessia Bagattin & Nicolas Kuperwasser & Federica Roccio & Biagina Ruscica & Nicolas Goudin & Meriem Garfa-Traoré & Alice Regnier & Lisa Turinsky & Martine Burti, 2023. "The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Sarah E. Conduit & Wayne Pearce & Amandeep Bhamra & Benoit Bilanges & Laura Bozal-Basterra & Lazaros C. Foukas & Mathias Cobbaut & Sandra D. Castillo & Mohammad Amin Danesh & Mahreen Adil & Arkaitz Ca, 2024. "A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    3. Muqing Cao & Xiaoxiao Zou & Chaoyi Li & Zaisheng Lin & Ni Wang & Zhongju Zou & Youqiong Ye & Joachim Seemann & Beth Levine & Zaiming Tang & Qing Zhong, 2023. "An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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