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Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens

Author

Listed:
  • Katharine M. Ng

    (Stanford University School of Medicine)

  • Jessica A. Ferreyra

    (Stanford University School of Medicine)

  • Steven K. Higginbottom

    (Stanford University School of Medicine)

  • Jonathan B. Lynch

    (Stanford University School of Medicine)

  • Purna C. Kashyap

    (Stanford University School of Medicine
    Present address: Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA.)

  • Smita Gopinath

    (Stanford University School of Medicine)

  • Natasha Naidu

    (Glycobiology Research and Training Center, University of California)

  • Biswa Choudhury

    (Glycobiology Research and Training Center, University of California)

  • Bart C. Weimer

    (University of California)

  • Denise M. Monack

    (Stanford University School of Medicine)

  • Justin L. Sonnenburg

    (Stanford University School of Medicine)

Abstract

Antibiotic treatment disturbs the commensal microbiota and is often followed by infection with enteric pathogens such as Salmonella typhimurium and Clostridium difficile; pathogen expansion is fuelled by antibiotic-driven accumulation of commensal-liberated host mucosal carbohydrates.

Suggested Citation

  • Katharine M. Ng & Jessica A. Ferreyra & Steven K. Higginbottom & Jonathan B. Lynch & Purna C. Kashyap & Smita Gopinath & Natasha Naidu & Biswa Choudhury & Bart C. Weimer & Denise M. Monack & Justin L., 2013. "Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens," Nature, Nature, vol. 502(7469), pages 96-99, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7469:d:10.1038_nature12503
    DOI: 10.1038/nature12503
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    Citations

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    Cited by:

    1. Vinod Nikhra, 2019. "Therapeutic Potential of Gut Microbiome Manipulation: Concepts in Fecal Microbiota Transplantation," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 11(1), pages 9-17, June.
    2. James D Brunner & Nicholas Chia, 2020. "Minimizing the number of optimizations for efficient community dynamic flux balance analysis," PLOS Computational Biology, Public Library of Science, vol. 16(9), pages 1-20, September.
    3. Vinod Nikhra, 2019. "Therapeutic Potential of Gut Microbiome Manipulation: Concepts in Fecal Microbiota Transplantation," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 11(1), pages 1-9, June.
    4. Randy Hamchand & Kevin Wang & Deguang Song & Noah W. Palm & Jason M. Crawford, 2024. "Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    5. Alexander Y. G. Yip & Olivia G. King & Oleksii Omelchenko & Sanjana Kurkimat & Victoria Horrocks & Phoebe Mostyn & Nathan Danckert & Rohma Ghani & Giovanni Satta & Elita Jauneikaite & Frances J. Davie, 2023. "Antibiotics promote intestinal growth of carbapenem-resistant Enterobacteriaceae by enriching nutrients and depleting microbial metabolites," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    6. Giuliano Bonanomi & Mohamed Idbella & Ahmed M. Abd-ElGawad, 2021. "Microbiota Management for Effective Disease Suppression: A Systematic Comparison between Soil and Mammals Gut," Sustainability, MDPI, vol. 13(14), pages 1-16, July.
    7. Naomi Ohta & Bo Norby & Guy H Loneragan & Javier Vinasco & Henk C den Bakker & Sara D Lawhon & Keri N Norman & Harvey M Scott, 2019. "Quantitative dynamics of Salmonella and E. coli in feces of feedlot cattle treated with ceftiofur and chlortetracycline," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-17, December.
    8. Jordy Evan Sulaiman & Jaron Thompson & Yili Qian & Eugenio I. Vivas & Christian Diener & Sean M. Gibbons & Nasia Safdar & Ophelia S. Venturelli, 2024. "Elucidating human gut microbiota interactions that robustly inhibit diverse Clostridioides difficile strains across different nutrient landscapes," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    9. Elvin Koh & In Young Hwang & Hui Ling Lee & Ryan De Sotto & Jonathan Wei Jie Lee & Yung Seng Lee & John C. March & Matthew Wook Chang, 2022. "Engineering probiotics to inhibit Clostridioides difficile infection by dynamic regulation of intestinal metabolism," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    10. K. E. Huus & T. T. Hoang & A. Creus-Cuadros & M. Cirstea & S. L. Vogt & K. Knuff-Janzen & P. J. Sansonetti & P. Vonaesch & B. B. Finlay, 2021. "Cross-feeding between intestinal pathobionts promotes their overgrowth during undernutrition," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    11. Ren Dodge & Eric W. Jones & Haolong Zhu & Benjamin Obadia & Daniel J. Martinez & Chenhui Wang & Andrés Aranda-Díaz & Kevin Aumiller & Zhexian Liu & Marco Voltolini & Eoin L. Brodie & Kerwyn Casey Huan, 2023. "A symbiotic physical niche in Drosophila melanogaster regulates stable association of a multi-species gut microbiota," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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