IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v501y2013i7467d10.1038_nature12452.html
   My bibliography  Save this article

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

Author

Listed:
  • Maria A. Ermolaeva

    (Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany)

  • Alexandra Segref

    (Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany)

  • Alexander Dakhovnik

    (Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany)

  • Hui-Ling Ou

    (Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany)

  • Jennifer I. Schneider

    (Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany)

  • Olaf Utermöhlen

    (Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Goldenfelsstrasse 19-21, 50935 Cologne, Germany
    Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany)

  • Thorsten Hoppe

    (Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany)

  • Björn Schumacher

    (Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
    Systems Biology of Ageing Cologne, University of Cologne, 50937 Cologne, Germany)

Abstract

In Caenorhabditis elegans, genome instability in the form of exogenous and endogenous DNA damage in germ cells evokes elevated heat- and oxidative-stress resistance in somatic tissues; this is mediated by MPK-1, which triggers the induction of putative secreted peptides associated with innate immunity, leading to activation of the ubiquitin–proteasome system.

Suggested Citation

  • Maria A. Ermolaeva & Alexandra Segref & Alexander Dakhovnik & Hui-Ling Ou & Jennifer I. Schneider & Olaf Utermöhlen & Thorsten Hoppe & Björn Schumacher, 2013. "DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance," Nature, Nature, vol. 501(7467), pages 416-420, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7467:d:10.1038_nature12452
    DOI: 10.1038/nature12452
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12452
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12452?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Liankui Zhou & Liu Jiang & Lan Li & Chengchuan Ma & Peixue Xia & Wanqiu Ding & Ying Liu, 2024. "A germline-to-soma signal triggers an age-related decline of mitochondrial stress response," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Hai Wei & Yi M. Weaver & Benjamin P. Weaver, 2024. "Xeroderma pigmentosum protein XPD controls caspase-mediated stress responses," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Najmeh Soltanmohammadi & Siyao Wang & Björn Schumacher, 2022. "Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:501:y:2013:i:7467:d:10.1038_nature12452. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.