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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

Author

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  • Mathias Jucker

    (Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany
    DZNE, German Center for Neurodegenerative Diseases, D-72076 Tübingen, Germany)

  • Lary C. Walker

    (Yerkes National Primate Research Center, Emory University
    Emory University)

Abstract

The prion paradigm – the hypothesis that the seeded aggregation of certain proteins is key to understanding age-related neurodegenerative disorders – is evaluated in relation to recent studies and disease models; the paradigm suggests a unifying pathogenic principle with broad relevance to a large class of currently intractable diseases.

Suggested Citation

  • Mathias Jucker & Lary C. Walker, 2013. "Self-propagation of pathogenic protein aggregates in neurodegenerative diseases," Nature, Nature, vol. 501(7465), pages 45-51, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7465:d:10.1038_nature12481
    DOI: 10.1038/nature12481
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    Cited by:

    1. Christine Rother & Ruth E. Uhlmann & Stephan A. Müller & Juliane Schelle & Angelos Skodras & Ulrike Obermüller & Lisa M. Häsler & Marius Lambert & Frank Baumann & Ying Xu & Carina Bergmann & Giulia Sa, 2022. "Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Benedikt Frieg & Mookyoung Han & Karin Giller & Christian Dienemann & Dietmar Riedel & Stefan Becker & Loren B. Andreas & Christian Griesinger & Gunnar F. Schröder, 2024. "Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Feng Han & Xufu Liu & Richard B. Mailman & Xuemei Huang & Xiao Liu, 2023. "Resting-state global brain activity affects early β-amyloid accumulation in default mode network," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Stacy A. Hussong & Andy Q. Banh & Candice E. Skike & Angela O. Dorigatti & Stephen F. Hernandez & Matthew J. Hart & Beatriz Ferran & Haneen Makhlouf & Maria Gaczynska & Pawel A. Osmulski & Salome A. M, 2023. "Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Hannah Drew Rickner & Lulu Jiang & Rui Hong & Nicholas K. O’Neill & Chromewell A. Mojica & Benjamin J. Snyder & Lushuang Zhang & Dipan Shaw & Maria Medalla & Benjamin Wolozin & Christine S. Cheng, 2022. "Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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