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Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing

Author

Listed:
  • Zhigang Xue

    (Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine)

  • Kevin Huang

    (David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA)

  • Chaochao Cai

    (David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA)

  • Lingbo Cai

    (State Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University)

  • Chun-yan Jiang

    (State Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University)

  • Yun Feng

    (Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine)

  • Zhenshan Liu

    (Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine)

  • Qiao Zeng

    (Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine)

  • Liming Cheng

    (Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine)

  • Yi E. Sun

    (Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine)

  • Jia-yin Liu

    (State Key Laboratory of Reproductive Medicine, Center of Clinical Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University)

  • Steve Horvath

    (David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA)

  • Guoping Fan

    (David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA)

Abstract

Single-cell RNA sequencing and weighted gene co-expression network analysis are used to study transcriptome change in pre-implantation embryos and oocytes; this reveals a conserved genetic program between human and mouse but with different developmental specificity and timing, and conserved hub genes that may be key in pre-implantation development.

Suggested Citation

  • Zhigang Xue & Kevin Huang & Chaochao Cai & Lingbo Cai & Chun-yan Jiang & Yun Feng & Zhenshan Liu & Qiao Zeng & Liming Cheng & Yi E. Sun & Jia-yin Liu & Steve Horvath & Guoping Fan, 2013. "Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing," Nature, Nature, vol. 500(7464), pages 593-597, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7464:d:10.1038_nature12364
    DOI: 10.1038/nature12364
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    Cited by:

    1. Mingyue Guo & Jinyi Wu & Chuanxin Chen & Xinggu Wang & An Gong & Wei Guan & Rowan M. Karvas & Kexin Wang & Mingwei Min & Yixuan Wang & Thorold W. Theunissen & Shaorong Gao & José C. R. Silva, 2024. "Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Denis Torre & Nancy J. Francoeur & Yael Kalma & Ilana Gross Carmel & Betsaida S. Melo & Gintaras Deikus & Kimaada Allette & Ron Flohr & Maya Fridrikh & Konstantinos Vlachos & Kent Madrid & Hardik Shah, 2023. "Isoform-resolved transcriptome of the human preimplantation embryo," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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