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PAAR-repeat proteins sharpen and diversify the type VI secretion system spike

Author

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  • Mikhail M. Shneider

    (École Polytechnique Fédérale de Lausanne (EPFL), BSP-415, 1015 Lausanne, Switzerland
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Laboratory of Molecular Bioengineering, 16/10 Miklukho-Maklaya Street, 117997 Moscow, Russia)

  • Sergey A. Buth

    (École Polytechnique Fédérale de Lausanne (EPFL), BSP-415, 1015 Lausanne, Switzerland)

  • Brian T. Ho

    (Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Marek Basler

    (Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • John J. Mekalanos

    (Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Petr G. Leiman

    (École Polytechnique Fédérale de Lausanne (EPFL), BSP-415, 1015 Lausanne, Switzerland)

Abstract

An X-ray structure of bacterial type VI secretion system components reveals that PAAR family proteins bind at the tip of the VgrG spike, providing new insights into the mechanisms of type VI secretion; experiments using bacteria confirmed the importance of PAAR proteins.

Suggested Citation

  • Mikhail M. Shneider & Sergey A. Buth & Brian T. Ho & Marek Basler & John J. Mekalanos & Petr G. Leiman, 2013. "PAAR-repeat proteins sharpen and diversify the type VI secretion system spike," Nature, Nature, vol. 500(7462), pages 350-353, August.
    • Handle: RePEc:nat:nature:v:500:y:2013:i:7462:d:10.1038_nature12453
    DOI: 10.1038/nature12453
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    Cited by:

    1. Dukas Jurėnas & Leonardo Talachia Rosa & Martial Rey & Julia Chamot-Rooke & Rémi Fronzes & Eric Cascales, 2021. "Mounting, structure and autocleavage of a type VI secretion-associated Rhs polymorphic toxin," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Katarzyna Kanarek & Chaya Mushka Fridman & Eran Bosis & Dor Salomon, 2023. "The RIX domain defines a class of polymorphic T6SS effectors and secreted adaptors," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Thibault R. Bongiovanni & Casey J. Latario & Youn Cras & Evan Trus & Sophie Robitaille & Kerry Swartz & Danica Schmidtke & Maxence Vincent & Artemis Kosta & Jan Orth & Florian Stengel & Riccardo Pella, 2024. "Assembly of a unique membrane complex in type VI secretion systems of Bacteroidota," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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