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Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome

Author

Listed:
  • Sheetal R. Modi

    (Howard Hughes Medical Institute, and Center for BioDynamics, Boston University)

  • Henry H. Lee

    (Howard Hughes Medical Institute, and Center for BioDynamics, Boston University
    Present address: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.)

  • Catherine S. Spina

    (Howard Hughes Medical Institute, and Center for BioDynamics, Boston University
    Boston University School of Medicine, 715 Albany Street
    Wyss Institute for Biologically Inspired Engineering, Harvard University)

  • James J. Collins

    (Howard Hughes Medical Institute, and Center for BioDynamics, Boston University
    Boston University School of Medicine, 715 Albany Street
    Wyss Institute for Biologically Inspired Engineering, Harvard University)

Abstract

By exploring the phageome in mice, antibiotic treatment is shown to lead to enrichment of phage-encoded genes that are related to antibiotic resistance.

Suggested Citation

  • Sheetal R. Modi & Henry H. Lee & Catherine S. Spina & James J. Collins, 2013. "Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome," Nature, Nature, vol. 499(7457), pages 219-222, July.
  • Handle: RePEc:nat:nature:v:499:y:2013:i:7457:d:10.1038_nature12212
    DOI: 10.1038/nature12212
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    Citations

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    Cited by:

    1. Rohan Maddamsetti & Yi Yao & Teng Wang & Junheng Gao & Vincent T. Huang & Grayson S. Hamrick & Hye-In Son & Lingchong You, 2024. "Duplicated antibiotic resistance genes reveal ongoing selection and horizontal gene transfer in bacteria," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Patrick Munk & Christian Brinch & Frederik Duus Møller & Thomas N. Petersen & Rene S. Hendriksen & Anne Mette Seyfarth & Jette S. Kjeldgaard & Christina Aaby Svendsen & Bram Bunnik & Fanny Berglund & , 2022. "Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Friederike S Rossmann & Tomas Racek & Dominique Wobser & Jacek Puchalka & Elaine M Rabener & Matthias Reiger & Antoni P A Hendrickx & Ann-Kristin Diederich & Kirsten Jung & Christoph Klein & Johannes , 2015. "Phage-mediated Dispersal of Biofilm and Distribution of Bacterial Virulence Genes Is Induced by Quorum Sensing," PLOS Pathogens, Public Library of Science, vol. 11(2), pages 1-17, February.
    4. Shao-Ming Gao & Han-Lan Fei & Qi Li & Li-Ying Lan & Li-Nan Huang & Peng-Fei Fan, 2024. "Eco-evolutionary dynamics of gut phageome in wild gibbons (Hoolock tianxing) with seasonal diet variations," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Suzanne Humphrey & Álvaro San Millán & Macarena Toll-Riera & John Connolly & Alejandra Flor-Duro & John Chen & Carles Ubeda & R. Craig MacLean & José R. Penadés, 2021. "Staphylococcal phages and pathogenicity islands drive plasmid evolution," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    6. Milva Pepi & Silvano Focardi, 2021. "Antibiotic-Resistant Bacteria in Aquaculture and Climate Change: A Challenge for Health in the Mediterranean Area," IJERPH, MDPI, vol. 18(11), pages 1-31, May.

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