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Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation

Author

Listed:
  • Wenbo Li

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Dimple Notani

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Qi Ma

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Graduate Program in Bioinformatics, University of California, San Diego, La Jolla, California 92093, USA)

  • Bogdan Tanasa

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Graduate Program, Kellogg School of Science and Technology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Esperanza Nunez

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Aaron Yun Chen

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Daria Merkurjev

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Graduate Program in Bioinformatics, University of California, San Diego, La Jolla, California 92093, USA)

  • Jie Zhang

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Kenneth Ohgi

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Xiaoyuan Song

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Soohwan Oh

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Graduate Program in Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA)

  • Hong-Sook Kim

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Christopher K. Glass

    (Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA)

  • Michael G. Rosenfeld

    (Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA)

Abstract

It is unclear whether bidirectional non-coding RNAs transcribed from enhancer elements (eRNAs) have any functional role; here, eRNA transcription is shown to be functionally important during the activation of genes by the oestrogen receptor in human breast cancer cells.

Suggested Citation

  • Wenbo Li & Dimple Notani & Qi Ma & Bogdan Tanasa & Esperanza Nunez & Aaron Yun Chen & Daria Merkurjev & Jie Zhang & Kenneth Ohgi & Xiaoyuan Song & Soohwan Oh & Hong-Sook Kim & Christopher K. Glass & M, 2013. "Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation," Nature, Nature, vol. 498(7455), pages 516-520, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7455:d:10.1038_nature12210
    DOI: 10.1038/nature12210
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    Cited by:

    1. Vladyslava Gorbovytska & Seung-Kyoon Kim & Filiz Kuybu & Michael Götze & Dahun Um & Keunsoo Kang & Andreas Pittroff & Theresia Brennecke & Lisa-Marie Schneider & Alexander Leitner & Tae-Kyung Kim & Cl, 2022. "Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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