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cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

Author

Listed:
  • Andrea Ablasser

    (Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Marion Goldeck

    (Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Taner Cavlar

    (Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Tobias Deimling

    (Ludwig-Maximilians-University, 81377 Munich, Germany)

  • Gregor Witte

    (Ludwig-Maximilians-University, 81377 Munich, Germany)

  • Ingo Röhl

    (Axolabs GmbH, 95326 Kulmbach, Germany)

  • Karl-Peter Hopfner

    (Ludwig-Maximilians-University, 81377 Munich, Germany
    Center for Integrated Protein Sciences, 81377 Munich, Germany)

  • Janos Ludwig

    (Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany)

  • Veit Hornung

    (Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany)

Abstract

Cytosolic DNA induces type I interferon via activation of STING; the immediate STING activator is produced by the recently identified DNA sensor cGAS and is shown here to be an unorthodox cyclic dinucleotide harbouring a 2′-5′ linkage between guanosine and adenosine.

Suggested Citation

  • Andrea Ablasser & Marion Goldeck & Taner Cavlar & Tobias Deimling & Gregor Witte & Ingo Röhl & Karl-Peter Hopfner & Janos Ludwig & Veit Hornung, 2013. "cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING," Nature, Nature, vol. 498(7454), pages 380-384, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7454:d:10.1038_nature12306
    DOI: 10.1038/nature12306
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    Citations

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    Cited by:

    1. Wen Zhou & Desmond Richmond-Buccola & Qiannan Wang & Philip J. Kranzusch, 2022. "Structural basis of human TREX1 DNA degradation and autoimmune disease," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Xuan Wang & Yingqi Liu & Chencheng Xue & Yan Hu & Yuanyuan Zhao & Kaiyong Cai & Menghuan Li & Zhong Luo, 2022. "A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    3. Niranjana Natarajan & Jonathan Florentin & Ebin Johny & Hanxi Xiao & Scott Patrick O’Neil & Liqun Lei & Jixing Shen & Lee Ohayon & Aaron R. Johnson & Krithika Rao & Xiaoyun Li & Yanwu Zhao & Yingze Zh, 2024. "Aberrant mitochondrial DNA synthesis in macrophages exacerbates inflammation and atherosclerosis," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Lingzhen Kong & Chen Cheng & Abigael Cheruiyot & Jiayi Yuan & Yichan Yang & Sydney Hwang & Daniel Foust & Ning Tsao & Emily Wilkerson & Nima Mosammaparast & Michael B. Major & David W. Piston & Shan L, 2024. "TCAF1 promotes TRPV2-mediated Ca2+ release in response to cytosolic DNA to protect stressed replication forks," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    5. Tomalika R. Ullah & Matt D. Johansen & Katherine R. Balka & Rebecca L. Ambrose & Linden J. Gearing & James Roest & Julian P. Vivian & Sunil Sapkota & W. Samantha N. Jayasekara & Daniel S. Wenholz & Vi, 2023. "Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    6. Jing Liu & Xia Bu & Chen Chu & Xiaoming Dai & John M. Asara & Piotr Sicinski & Gordon J. Freeman & Wenyi Wei, 2023. "PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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