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MBNL proteins repress ES-cell-specific alternative splicing and reprogramming

Author

Listed:
  • Hong Han

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Manuel Irimia

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • P. Joel Ross

    (Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College Street, Toronto, Ontario M5G 1L7, Canada)

  • Hoon-Ki Sung

    (Center for Stem Cells and Tissue Engineering, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada)

  • Babak Alipanahi

    (University of Toronto, Toronto, Ontario M5S 3G4, Canada)

  • Laurent David

    (Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada)

  • Azadeh Golipour

    (University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada)

  • Mathieu Gabut

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Iacovos P. Michael

    (Center for Stem Cells and Tissue Engineering, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada)

  • Emil N. Nachman

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Eric Wang

    (Massachusetts Institute of Technology)

  • Dan Trcka

    (Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada)

  • Tadeo Thompson

    (Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College Street, Toronto, Ontario M5G 1L7, Canada)

  • Dave O’Hanlon

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Valentina Slobodeniuc

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Nuno L. Barbosa-Morais

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal)

  • Christopher B. Burge

    (Massachusetts Institute of Technology)

  • Jason Moffat

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Brendan J. Frey

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada
    University of Toronto, Toronto, Ontario M5S 3G4, Canada)

  • Andras Nagy

    (Center for Stem Cells and Tissue Engineering, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    University of Toronto, Toronto, Ontario, M5S 1A8, Canada)

  • James Ellis

    (University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College Street, Toronto, Ontario M5G 1L7, Canada)

  • Jeffrey L. Wrana

    (University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada)

  • Benjamin J. Blencowe

    (University of Toronto, Toronto, Ontario M5S 3E1, Canada
    University of Toronto, Toronto, Ontario M5S 1A8, Canada)

Abstract

This study identifies MBNL proteins as negative regulators of alternative splicing events that are differentially regulated between ES cells and other cell types; several lines of evidence show that these proteins repress an ES cell alternative splicing program and the reprogramming of somatic cells to induced pluripotent stem cells.

Suggested Citation

  • Hong Han & Manuel Irimia & P. Joel Ross & Hoon-Ki Sung & Babak Alipanahi & Laurent David & Azadeh Golipour & Mathieu Gabut & Iacovos P. Michael & Emil N. Nachman & Eric Wang & Dan Trcka & Tadeo Thomps, 2013. "MBNL proteins repress ES-cell-specific alternative splicing and reprogramming," Nature, Nature, vol. 498(7453), pages 241-245, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7453:d:10.1038_nature12270
    DOI: 10.1038/nature12270
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    Citations

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    Cited by:

    1. Xianke Xiang & Yao He & Zemin Zhang & Xuerui Yang, 2024. "Interrogations of single-cell RNA splicing landscapes with SCASL define new cell identities with physiological relevance," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Stacey D Wagner & Adam J Struck & Riti Gupta & Dylan R Farnsworth & Amy E Mahady & Katy Eichinger & Charles A Thornton & Eric T Wang & J Andrew Berglund, 2016. "Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy," PLOS Genetics, Public Library of Science, vol. 12(9), pages 1-24, September.

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