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Chromosome-specific nonrandom sister chromatid segregation during stem-cell division

Author

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  • Swathi Yadlapalli

    (Life Sciences Institute, Center for Stem Cell Biology, University of Michigan
    School of Medicine, University of Michigan)

  • Yukiko M. Yamashita

    (Life Sciences Institute, Center for Stem Cell Biology, University of Michigan
    School of Medicine, University of Michigan
    Cellular and Molecular Biology Program, University of Michigan)

Abstract

Using a CO-FISH method with single-chromosome resolution, sister chromatids of the sex chromosomes, but not autosomes, are shown to segregate nonrandomly during asymmetric cell divisions of Drosophila male germline stem cells; this suggests that it is unlikely that nonrandom sister chromatid segregation serves to protect the ‘immortal strand’ to avoid replication-induced mutations as proposed previously.

Suggested Citation

  • Swathi Yadlapalli & Yukiko M. Yamashita, 2013. "Chromosome-specific nonrandom sister chromatid segregation during stem-cell division," Nature, Nature, vol. 498(7453), pages 251-254, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7453:d:10.1038_nature12106
    DOI: 10.1038/nature12106
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    Cited by:

    1. Matthew Antel & Romir Raj & Madona Y. G. Masoud & Ziwei Pan & Sheng Li & Barbara G. Mellone & Mayu Inaba, 2022. "Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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