IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v497y2013i7448d10.1038_nature12079.html
   My bibliography  Save this article

Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

Author

Listed:
  • Anna Cebula

    (Center for Biotechnology and Genomic Medicine, Georgia Regents University)

  • Michal Seweryn

    (Mathematical Biosciences Institute, College of Public Health, Ohio State University
    Faculty of Mathematics and Computer Science, University of Lodz)

  • Grzegorz A. Rempala

    (Mathematical Biosciences Institute, College of Public Health, Ohio State University)

  • Simarjot Singh Pabla

    (Center for Biotechnology and Genomic Medicine, Georgia Regents University)

  • Richard A. McIndoe

    (Center for Biotechnology and Genomic Medicine, Georgia Regents University)

  • Timothy L. Denning

    (Emory University)

  • Lynn Bry

    (Brigham and Women's Hospital, Harvard Medical School)

  • Piotr Kraj

    (Center for Biotechnology and Genomic Medicine, Georgia Regents University)

  • Pawel Kisielow

    (Ludwik Hirszfeld Institute of Immunology and Experimental Therapy)

  • Leszek Ignatowicz

    (Center for Biotechnology and Genomic Medicine, Georgia Regents University)

Abstract

By using high-throughput sequencing of T-cell receptors, this study shows that thymus-derived regulatory T (Treg) cells constitute most Treg cells in all lymphoid and intestinal organs, including the colon, suggesting that thymic Treg cells and not induced Treg cells dominantly control tolerance to the gut’s antigens such as commensal microbiota.

Suggested Citation

  • Anna Cebula & Michal Seweryn & Grzegorz A. Rempala & Simarjot Singh Pabla & Richard A. McIndoe & Timothy L. Denning & Lynn Bry & Piotr Kraj & Pawel Kisielow & Leszek Ignatowicz, 2013. "Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota," Nature, Nature, vol. 497(7448), pages 258-262, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7448:d:10.1038_nature12079
    DOI: 10.1038/nature12079
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12079
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12079?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Maciej Pietrzak & Grzegorz A. Rempała & Michał Seweryn & Jacek Wesołowski, 2016. "Limit theorems for empirical Rényi entropy and divergence with applications to molecular diversity analysis," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 25(4), pages 654-673, December.
    2. Pedro Jeferson Miranda & Murilo Delgobo & Giovani Favero Marino & Kátia Sabrina Paludo & Murilo da Silva Baptista & Sandro Ely de Souza Pinto, 2015. "The Oral Tolerance as a Complex Network Phenomenon," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-17, June.
    3. Elisabeth H. Vollmann & Kristin Rattay & Olga Barreiro & Aude Thiriot & Rebecca A. Fuhlbrigge & Vladimir Vrbanac & Ki-Wook Kim & Steffen Jung & Andrew M. Tager & Ulrich H. von Andrian, 2021. "Specialized transendothelial dendritic cells mediate thymic T-cell selection against blood-borne macromolecules," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:497:y:2013:i:7448:d:10.1038_nature12079. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.