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Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

Author

Listed:
  • Anna Cebula

    (Center for Biotechnology and Genomic Medicine, Georgia Regents University)

  • Michal Seweryn

    (Mathematical Biosciences Institute, College of Public Health, Ohio State University
    Faculty of Mathematics and Computer Science, University of Lodz)

  • Grzegorz A. Rempala

    (Mathematical Biosciences Institute, College of Public Health, Ohio State University)

  • Simarjot Singh Pabla

    (Center for Biotechnology and Genomic Medicine, Georgia Regents University)

  • Richard A. McIndoe

    (Center for Biotechnology and Genomic Medicine, Georgia Regents University)

  • Timothy L. Denning

    (Emory University)

  • Lynn Bry

    (Brigham and Women's Hospital, Harvard Medical School)

  • Piotr Kraj

    (Center for Biotechnology and Genomic Medicine, Georgia Regents University)

  • Pawel Kisielow

    (Ludwik Hirszfeld Institute of Immunology and Experimental Therapy)

  • Leszek Ignatowicz

    (Center for Biotechnology and Genomic Medicine, Georgia Regents University)

Abstract

By using high-throughput sequencing of T-cell receptors, this study shows that thymus-derived regulatory T (Treg) cells constitute most Treg cells in all lymphoid and intestinal organs, including the colon, suggesting that thymic Treg cells and not induced Treg cells dominantly control tolerance to the gut’s antigens such as commensal microbiota.

Suggested Citation

  • Anna Cebula & Michal Seweryn & Grzegorz A. Rempala & Simarjot Singh Pabla & Richard A. McIndoe & Timothy L. Denning & Lynn Bry & Piotr Kraj & Pawel Kisielow & Leszek Ignatowicz, 2013. "Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota," Nature, Nature, vol. 497(7448), pages 258-262, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7448:d:10.1038_nature12079
    DOI: 10.1038/nature12079
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    Cited by:

    1. Maciej Pietrzak & Grzegorz A. Rempała & Michał Seweryn & Jacek Wesołowski, 2016. "Limit theorems for empirical Rényi entropy and divergence with applications to molecular diversity analysis," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 25(4), pages 654-673, December.
    2. Elisabeth H. Vollmann & Kristin Rattay & Olga Barreiro & Aude Thiriot & Rebecca A. Fuhlbrigge & Vladimir Vrbanac & Ki-Wook Kim & Steffen Jung & Andrew M. Tager & Ulrich H. von Andrian, 2021. "Specialized transendothelial dendritic cells mediate thymic T-cell selection against blood-borne macromolecules," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    3. Pedro Jeferson Miranda & Murilo Delgobo & Giovani Favero Marino & Kátia Sabrina Paludo & Murilo da Silva Baptista & Sandro Ely de Souza Pinto, 2015. "The Oral Tolerance as a Complex Network Phenomenon," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-17, June.

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