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A CRISPR/Cas system mediates bacterial innate immune evasion and virulence

Author

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  • Timothy R. Sampson

    (Microbiology and Molecular Genetics Program, Emory University
    Emory Vaccine Center, Emory University
    Yerkes National Primate Research Center, Emory University)

  • Sunil D. Saroj

    (Emory University School of Medicine)

  • Anna C. Llewellyn

    (Microbiology and Molecular Genetics Program, Emory University
    Emory Vaccine Center, Emory University
    Yerkes National Primate Research Center, Emory University)

  • Yih-Ling Tzeng

    (Emory University School of Medicine)

  • David S. Weiss

    (Emory Vaccine Center, Emory University
    Yerkes National Primate Research Center, Emory University
    Emory University School of Medicine)

Abstract

The CRISPR/Cas system known to aid bacterial defences by targeting invading DNA can also act to evade eukaryotic defences through a different class of small RNAs downregulating an endogenous immunogenic bacterial lipoprotein.

Suggested Citation

  • Timothy R. Sampson & Sunil D. Saroj & Anna C. Llewellyn & Yih-Ling Tzeng & David S. Weiss, 2013. "A CRISPR/Cas system mediates bacterial innate immune evasion and virulence," Nature, Nature, vol. 497(7448), pages 254-257, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7448:d:10.1038_nature12048
    DOI: 10.1038/nature12048
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    Cited by:

    1. Gabriel Magno Freitas Almeida & Ville Hoikkala & Janne Ravantti & Noora Rantanen & Lotta-Riina Sundberg, 2022. "Mucin induces CRISPR-Cas defense in an opportunistic pathogen," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Mingfang Bi & Wenjing Su & Jiafu Li & Xiaobing Mo, 2024. "Insights into the inhibition of protospacer integration via direct interaction between Cas2 and AcrVA5," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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