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Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX

Author

Listed:
  • Myunggon Ko

    (La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA)

  • Jungeun An

    (La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA)

  • Hozefa S. Bandukwala

    (La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA)

  • Lukas Chavez

    (La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA)

  • Tarmo Äijö

    (La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA
    Aalto University School of Science)

  • William A. Pastor

    (La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA
    Present addresses: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Terasaki Life Sciences Building, 610 Charles Young Drive East, Los Angeles, California 90095-723905, USA (W.A.P.); Bristol-Myers Squibb, 700 Bay Road, Redwood City, California 94063, USA (H.Li); KU Leuven Department of Development and Regeneration & Stem Cell Institute Leuven, Herestraat 49, 3000 Leuven, Belgium (K.P.K.).)

  • Matthew F. Segal

    (La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA)

  • Huiming Li

    (Harvard Medical School and Program in Cellular and Molecular Medicine, Children’s Hospital, Boston, Massachusetts 02115, USA
    Present addresses: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Terasaki Life Sciences Building, 610 Charles Young Drive East, Los Angeles, California 90095-723905, USA (W.A.P.); Bristol-Myers Squibb, 700 Bay Road, Redwood City, California 94063, USA (H.Li); KU Leuven Department of Development and Regeneration & Stem Cell Institute Leuven, Herestraat 49, 3000 Leuven, Belgium (K.P.K.).)

  • Kian Peng Koh

    (Harvard Medical School and Program in Cellular and Molecular Medicine, Children’s Hospital, Boston, Massachusetts 02115, USA
    Present addresses: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Terasaki Life Sciences Building, 610 Charles Young Drive East, Los Angeles, California 90095-723905, USA (W.A.P.); Bristol-Myers Squibb, 700 Bay Road, Redwood City, California 94063, USA (H.Li); KU Leuven Department of Development and Regeneration & Stem Cell Institute Leuven, Herestraat 49, 3000 Leuven, Belgium (K.P.K.).)

  • Harri Lähdesmäki

    (Aalto University School of Science)

  • Patrick G. Hogan

    (La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA)

  • L. Aravind

    (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA)

  • Anjana Rao

    (La Jolla Institute for Allergy & Immunology, La Jolla, California 92037, USA
    Harvard Medical School and Program in Cellular and Molecular Medicine, Children’s Hospital, Boston, Massachusetts 02115, USA
    Sanford Consortium for Regenerative Medicine, La Jolla, California 92037, USA)

Abstract

The CXXC domains of TET2 (encoded by the distinct gene IDAX) and TET3 are found to have previously unknown roles in the regulation of TET proteins through the activation of caspases and subsequent reduction in TET catalytic activity; this regulation is dependent on DNA binding through the CXXC domain.

Suggested Citation

  • Myunggon Ko & Jungeun An & Hozefa S. Bandukwala & Lukas Chavez & Tarmo Äijö & William A. Pastor & Matthew F. Segal & Huiming Li & Kian Peng Koh & Harri Lähdesmäki & Patrick G. Hogan & L. Aravind & Anj, 2013. "Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX," Nature, Nature, vol. 497(7447), pages 122-126, May.
    • Handle: RePEc:nat:nature:v:497:y:2013:i:7447:d:10.1038_nature12052
    DOI: 10.1038/nature12052
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    Cited by:

    1. Yu-Jung Tseng & Yuki Kageyama & Rebecca L. Murdaugh & Ayumi Kitano & Jong Hwan Kim & Kevin A. Hoegenauer & Jonathan Tiessen & Mackenzie H. Smith & Hidetaka Uryu & Koichi Takahashi & James F. Martin & , 2024. "Increased iron uptake by splenic hematopoietic stem cells promotes TET2-dependent erythroid regeneration," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. María Arroyo & Florian D. Hastert & Andreas Zhadan & Florian Schelter & Susanne Zimbelmann & Cathia Rausch & Anne K. Ludwig & Thomas Carell & M. Cristina Cardoso, 2022. "Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation," Nature Communications, Nature, vol. 13(1), pages 1-28, December.

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