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CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

Author

Listed:
  • Adam Greenbaum

    (Washington University School of Medicine)

  • Yen-Michael S. Hsu

    (Washington University School of Medicine)

  • Ryan B. Day

    (Washington University School of Medicine)

  • Laura G. Schuettpelz

    (Washington University School of Medicine)

  • Matthew J. Christopher

    (Washington University School of Medicine)

  • Joshua N. Borgerding

    (Washington University School of Medicine)

  • Takashi Nagasawa

    (Institute for Frontier Medical Sciences, Kyoto University
    Japan Science and Technology Agency, Core Research for Evolutionary Science and Technology, Tokyo 102-0075, Japan)

  • Daniel C. Link

    (Washington University School of Medicine)

Abstract

Targeted deletion of the chemokine Cxcl12 in different bone marrow stromal cell populations shows that distinct niches exist in the bone marrow for haematopoietic stem cells and lineage-committed progenitors.

Suggested Citation

  • Adam Greenbaum & Yen-Michael S. Hsu & Ryan B. Day & Laura G. Schuettpelz & Matthew J. Christopher & Joshua N. Borgerding & Takashi Nagasawa & Daniel C. Link, 2013. "CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance," Nature, Nature, vol. 495(7440), pages 227-230, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7440:d:10.1038_nature11926
    DOI: 10.1038/nature11926
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    Cited by:

    1. Trent D. Hall & Hyunjin Kim & Mahmoud Dabbah & Jacquelyn A. Myers & Jeremy Chase Crawford & Antonio Morales-Hernandez & Claire E. Caprio & Pramika Sriram & Emilia Kooienga & Marta Derecka & Esther A. , 2022. "Murine fetal bone marrow does not support functional hematopoietic stem and progenitor cells until birth," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Runfeng Miao & Harim Chun & Xing Feng & Ana Cordeiro Gomes & Jungmin Choi & João P. Pereira, 2022. "Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Christina M. Termini & Amara Pang & Tiancheng Fang & Martina Roos & Vivian Y. Chang & Yurun Zhang & Nicollette J. Setiawan & Lia Signaevskaia & Michelle Li & Mindy M. Kim & Orel Tabibi & Paulina K. Li, 2021. "Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    4. Yoshiki Omatsu & Shota Aiba & Tomonori Maeta & Kei Higaki & Kazunari Aoki & Hitomi Watanabe & Gen Kondoh & Riko Nishimura & Shu Takeda & Ung-il Chung & Takashi Nagasawa, 2022. "Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    5. Madison L. Doolittle & Dominik Saul & Japneet Kaur & Jennifer L. Rowsey & Stephanie J. Vos & Kevin D. Pavelko & Joshua N. Farr & David G. Monroe & Sundeep Khosla, 2023. "Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    6. Adrienne Anginot & Julie Nguyen & Zeina Abou Nader & Vincent Rondeau & Amélie Bonaud & Maria Kalogeraki & Antoine Boutin & Julia P. Lemos & Valeria Bisio & Joyce Koenen & Lea Hanna Doumit Sakr & Amand, 2023. "WHIM Syndrome-linked CXCR4 mutations drive osteoporosis," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    7. Jia Cao & Ling Jin & Zi-Qi Yan & Xiao-Kai Wang & You-You Li & Zun Wang & Yi-Wei Liu & Hong-Ming Li & Zhe Guan & Ze-Hui He & Jiang-Shan Gong & Jiang-Hua Liu & Hao Yin & Yi-Juan Tan & Chun-Gu Hong & Shi, 2023. "Reassessing endothelial-to-mesenchymal transition in mouse bone marrow: insights from lineage tracing models," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    8. Yang Liu & Qi Chen & Hyun-Woo Jeong & Bong Ihn Koh & Emma C. Watson & Cong Xu & Martin Stehling & Bin Zhou & Ralf H. Adams, 2022. "A specialized bone marrow microenvironment for fetal haematopoiesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    9. Kiyoka Saito & Mark Garde & Terumasa Umemoto & Natsumi Miharada & Julia Sjöberg & Valgardur Sigurdsson & Haruki Shirozu & Shunsuke Kamei & Visnja Radulovic & Mitsuyoshi Suzuki & Satoshi Nakano & Stefa, 2024. "Lipoprotein metabolism mediates hematopoietic stem cell responses under acute anemic conditions," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    10. Yuki Matsushita & Jialin Liu & Angel Ka Yan Chu & Chiaki Tsutsumi-Arai & Mizuki Nagata & Yuki Arai & Wanida Ono & Kouhei Yamamoto & Thomas L. Saunders & Joshua D. Welch & Noriaki Ono, 2023. "Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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