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GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas

Author

Listed:
  • Scott X. Atwood

    (Program in Epithelial Biology, Stanford University School of Medicine)

  • Mischa Li

    (Program in Epithelial Biology, Stanford University School of Medicine)

  • Alex Lee

    (Program in Epithelial Biology, Stanford University School of Medicine)

  • Jean Y. Tang

    (Program in Epithelial Biology, Stanford University School of Medicine)

  • Anthony E. Oro

    (Program in Epithelial Biology, Stanford University School of Medicine)

Abstract

Atypical protein kinase C ι/λ is shown to be critical, through its regulation of the transcription factor GLI, for hedgehog-dependent processes, such as the growth of basal cell carcinomas.

Suggested Citation

  • Scott X. Atwood & Mischa Li & Alex Lee & Jean Y. Tang & Anthony E. Oro, 2013. "GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas," Nature, Nature, vol. 494(7438), pages 484-488, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7438:d:10.1038_nature11889
    DOI: 10.1038/nature11889
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    Cited by:

    1. Sarah E. Conduit & Wayne Pearce & Amandeep Bhamra & Benoit Bilanges & Laura Bozal-Basterra & Lazaros C. Foukas & Mathias Cobbaut & Sandra D. Castillo & Mohammad Amin Danesh & Mahreen Adil & Arkaitz Ca, 2024. "A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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