IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v494y2013i7437d10.1038_nature11834.html
   My bibliography  Save this article

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

Author

Listed:
  • Ruisheng Song

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
    Institute of Cardiovascular Sciences, Health Science Center, Peking University)

  • Wei Peng

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Yan Zhang

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Fengxiang Lv

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Hong-Kun Wu

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Jiaojiao Guo

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Yongxing Cao

    (Institute of Sports Medicine, Peking University Third Hospital)

  • Yanbin Pi

    (Institute of Sports Medicine, Peking University Third Hospital)

  • Xin Zhang

    (Institute of Sports Medicine, Peking University Third Hospital)

  • Li Jin

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Mao Zhang

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Peng Jiang

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Fenghua Liu

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Shaoshuai Meng

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Xiuqin Zhang

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Ping Jiang

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Chun-Mei Cao

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Rui-Ping Xiao

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
    Center for Life Sciences, Peking University)

Abstract

MG53 acts as an E3 ligase that targets the insulin receptor and IRS1 for ubiquitin-dependent degradation; when MG53 is upregulated, metabolic syndrome ensues.

Suggested Citation

  • Ruisheng Song & Wei Peng & Yan Zhang & Fengxiang Lv & Hong-Kun Wu & Jiaojiao Guo & Yongxing Cao & Yanbin Pi & Xin Zhang & Li Jin & Mao Zhang & Peng Jiang & Fenghua Liu & Shaoshuai Meng & Xiuqin Zhang , 2013. "Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders," Nature, Nature, vol. 494(7437), pages 375-379, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7437:d:10.1038_nature11834
    DOI: 10.1038/nature11834
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11834
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11834?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Daewon Lee & Eunju Yoon & Su Jin Ham & Kunwoo Lee & Hansaem Jang & Daihn Woo & Da Hyun Lee & Sehyeon Kim & Sekyu Choi & Jongkyeong Chung, 2024. "Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    2. Wanbao Yang & Wen Jiang & Wang Liao & Hui Yan & Weiqi Ai & Quan Pan & Wesley A. Brashear & Yong Xu & Ling He & Shaodong Guo, 2024. "An estrogen receptor α-derived peptide improves glucose homeostasis during obesity," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Yuemin Ma & Lei Ding & Zhenhai Li & Chun Zhou, 2023. "Structural basis for TRIM72 oligomerization during membrane damage repair," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Fei Xie & Bin Liu & Wen Qiao & Jing-zhen He & Jie Cheng & Zhao-yang Wang & Ya-min Hou & Xu Zhang & Bo-han Xu & Yun Zhang & Yu-guo Chen & Ming-xiang Zhang, 2024. "Smooth muscle NF90 deficiency ameliorates diabetic atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs axis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:494:y:2013:i:7437:d:10.1038_nature11834. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.