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Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

Author

Listed:
  • Ruisheng Song

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
    Institute of Cardiovascular Sciences, Health Science Center, Peking University)

  • Wei Peng

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Yan Zhang

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Fengxiang Lv

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Hong-Kun Wu

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Jiaojiao Guo

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Yongxing Cao

    (Institute of Sports Medicine, Peking University Third Hospital)

  • Yanbin Pi

    (Institute of Sports Medicine, Peking University Third Hospital)

  • Xin Zhang

    (Institute of Sports Medicine, Peking University Third Hospital)

  • Li Jin

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Mao Zhang

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Peng Jiang

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Fenghua Liu

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Shaoshuai Meng

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Xiuqin Zhang

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Ping Jiang

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Chun-Mei Cao

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Rui-Ping Xiao

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University
    Center for Life Sciences, Peking University)

Abstract

MG53 acts as an E3 ligase that targets the insulin receptor and IRS1 for ubiquitin-dependent degradation; when MG53 is upregulated, metabolic syndrome ensues.

Suggested Citation

  • Ruisheng Song & Wei Peng & Yan Zhang & Fengxiang Lv & Hong-Kun Wu & Jiaojiao Guo & Yongxing Cao & Yanbin Pi & Xin Zhang & Li Jin & Mao Zhang & Peng Jiang & Fenghua Liu & Shaoshuai Meng & Xiuqin Zhang , 2013. "Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders," Nature, Nature, vol. 494(7437), pages 375-379, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7437:d:10.1038_nature11834
    DOI: 10.1038/nature11834
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    Cited by:

    1. Daewon Lee & Eunju Yoon & Su Jin Ham & Kunwoo Lee & Hansaem Jang & Daihn Woo & Da Hyun Lee & Sehyeon Kim & Sekyu Choi & Jongkyeong Chung, 2024. "Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    2. Yuemin Ma & Lei Ding & Zhenhai Li & Chun Zhou, 2023. "Structural basis for TRIM72 oligomerization during membrane damage repair," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Wanbao Yang & Wen Jiang & Wang Liao & Hui Yan & Weiqi Ai & Quan Pan & Wesley A. Brashear & Yong Xu & Ling He & Shaodong Guo, 2024. "An estrogen receptor α-derived peptide improves glucose homeostasis during obesity," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Fei Xie & Bin Liu & Wen Qiao & Jing-zhen He & Jie Cheng & Zhao-yang Wang & Ya-min Hou & Xu Zhang & Bo-han Xu & Yun Zhang & Yu-guo Chen & Ming-xiang Zhang, 2024. "Smooth muscle NF90 deficiency ameliorates diabetic atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs axis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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