IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v494y2013i7436d10.1038_nature11896.html
   My bibliography  Save this article

Molecular signatures of G-protein-coupled receptors

Author

Listed:
  • A. J. Venkatakrishnan

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Xavier Deupi

    (Paul Scherrer Institute, 5232 Villigen PSI, Switzerland)

  • Guillaume Lebon

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier F-34094, France
    INSERM, U661, Montpellier F-34094, France
    Universités de Montpellier 1 & 2, UMR-5203, Montpellier F-34094, France)

  • Christopher G. Tate

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Gebhard F. Schertler

    (Paul Scherrer Institute, 5232 Villigen PSI, Switzerland
    ETH Zürich, Wolfgang-Pauli-Str. 27, 8093 Zürich, Switzerland)

  • M. Madan Babu

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

Abstract

A systematic investigation of high-resolution G-protein-coupled receptor (GPCR) structures uncovers a conserved inter-helical network of non-covalent contacts that defines the GPCR fold, and provides insights into the molecular determinants of different GPCR conformations.

Suggested Citation

  • A. J. Venkatakrishnan & Xavier Deupi & Guillaume Lebon & Christopher G. Tate & Gebhard F. Schertler & M. Madan Babu, 2013. "Molecular signatures of G-protein-coupled receptors," Nature, Nature, vol. 494(7436), pages 185-194, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7436:d:10.1038_nature11896
    DOI: 10.1038/nature11896
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11896
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11896?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Chris Habrian & Naomi Latorraca & Zhu Fu & Ehud Y. Isacoff, 2023. "Homo- and hetero-dimeric subunit interactions set affinity and efficacy in metabotropic glutamate receptors," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Longjun Pu & Jing Wang & Qiongxuan Lu & Lars Nilsson & Alison Philbrook & Anjali Pandey & Lina Zhao & Robin van Schendel & Alan Koh & Tanara V. Peres & Weheliye H. Hashi & Si Lhyam Myint & Chloe Willi, 2023. "Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Yuxia Qian & Jiening Wang & Linlin Yang & Yanru Liu & Lina Wang & Wei Liu & Yun Lin & Hong Yang & Lixin Ma & Sheng Ye & Shan Wu & Anna Qiao, 2022. "Activation and signaling mechanism revealed by GPR119-Gs complex structures," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    4. Oliver Tejero & Filip Pamula & Mitsumasa Koyanagi & Takashi Nagata & Pavel Afanasyev & Ishita Das & Xavier Deupi & Mordechai Sheves & Akihisa Terakita & Gebhard F. X. Schertler & Matthew J. Rodrigues , 2024. "Active state structures of a bistable visual opsin bound to G proteins," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Mingyu Li & Xiaobing Lan & Xinchao Shi & Chunhao Zhu & Xun Lu & Jun Pu & Shaoyong Lu & Jian Zhang, 2024. "Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    6. Eyal Rozenfeld & Merav Tauber & Yair Ben-Chaim & Moshe Parnas, 2021. "GPCR voltage dependence controls neuronal plasticity and behavior," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    7. Aika Iwama & Ryoji Kise & Hiroaki Akasaka & Fumiya K. Sano & Hidetaka S. Oshima & Asuka Inoue & Wataru Shihoya & Osamu Nureki, 2024. "Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    8. Hiroaki Akasaka & Tatsuki Tanaka & Fumiya K. Sano & Yuma Matsuzaki & Wataru Shihoya & Osamu Nureki, 2022. "Structure of the active Gi-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    9. Gregory Zilberg & Alexandra K. Parpounas & Audrey L. Warren & Shifan Yang & Daniel Wacker, 2024. "Molecular basis of human trace amine-associated receptor 1 activation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    10. Sathvik Anantakrishnan & Athi N. Naganathan, 2023. "Thermodynamic architecture and conformational plasticity of GPCRs," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    11. Tamaki Izume & Ryo Kawahara & Akiharu Uwamizu & Luying Chen & Shun Yaginuma & Jumpei Omi & Hiroki Kawana & Fengjue Hou & Fumiya K. Sano & Tatsuki Tanaka & Kazuhiro Kobayashi & Hiroyuki H. Okamoto & Yo, 2024. "Structural basis for lysophosphatidylserine recognition by GPR34," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:494:y:2013:i:7436:d:10.1038_nature11896. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.