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Molecular signatures of G-protein-coupled receptors

Author

Listed:
  • A. J. Venkatakrishnan

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Xavier Deupi

    (Paul Scherrer Institute, 5232 Villigen PSI, Switzerland)

  • Guillaume Lebon

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier F-34094, France
    INSERM, U661, Montpellier F-34094, France
    Universités de Montpellier 1 & 2, UMR-5203, Montpellier F-34094, France)

  • Christopher G. Tate

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Gebhard F. Schertler

    (Paul Scherrer Institute, 5232 Villigen PSI, Switzerland
    ETH Zürich, Wolfgang-Pauli-Str. 27, 8093 Zürich, Switzerland)

  • M. Madan Babu

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

Abstract

A systematic investigation of high-resolution G-protein-coupled receptor (GPCR) structures uncovers a conserved inter-helical network of non-covalent contacts that defines the GPCR fold, and provides insights into the molecular determinants of different GPCR conformations.

Suggested Citation

  • A. J. Venkatakrishnan & Xavier Deupi & Guillaume Lebon & Christopher G. Tate & Gebhard F. Schertler & M. Madan Babu, 2013. "Molecular signatures of G-protein-coupled receptors," Nature, Nature, vol. 494(7436), pages 185-194, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7436:d:10.1038_nature11896
    DOI: 10.1038/nature11896
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    Citations

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    Cited by:

    1. Chris Habrian & Naomi Latorraca & Zhu Fu & Ehud Y. Isacoff, 2023. "Homo- and hetero-dimeric subunit interactions set affinity and efficacy in metabotropic glutamate receptors," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Longjun Pu & Jing Wang & Qiongxuan Lu & Lars Nilsson & Alison Philbrook & Anjali Pandey & Lina Zhao & Robin van Schendel & Alan Koh & Tanara V. Peres & Weheliye H. Hashi & Si Lhyam Myint & Chloe Willi, 2023. "Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Eyal Rozenfeld & Merav Tauber & Yair Ben-Chaim & Moshe Parnas, 2021. "GPCR voltage dependence controls neuronal plasticity and behavior," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    4. Sathvik Anantakrishnan & Athi N. Naganathan, 2023. "Thermodynamic architecture and conformational plasticity of GPCRs," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Tamaki Izume & Ryo Kawahara & Akiharu Uwamizu & Luying Chen & Shun Yaginuma & Jumpei Omi & Hiroki Kawana & Fengjue Hou & Fumiya K. Sano & Tatsuki Tanaka & Kazuhiro Kobayashi & Hiroyuki H. Okamoto & Yo, 2024. "Structural basis for lysophosphatidylserine recognition by GPR34," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Yuxia Qian & Jiening Wang & Linlin Yang & Yanru Liu & Lina Wang & Wei Liu & Yun Lin & Hong Yang & Lixin Ma & Sheng Ye & Shan Wu & Anna Qiao, 2022. "Activation and signaling mechanism revealed by GPR119-Gs complex structures," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    7. Mingyu Li & Xiaobing Lan & Xinchao Shi & Chunhao Zhu & Xun Lu & Jun Pu & Shaoyong Lu & Jian Zhang, 2024. "Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    8. Aika Iwama & Ryoji Kise & Hiroaki Akasaka & Fumiya K. Sano & Hidetaka S. Oshima & Asuka Inoue & Wataru Shihoya & Osamu Nureki, 2024. "Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    9. Hiroaki Akasaka & Tatsuki Tanaka & Fumiya K. Sano & Yuma Matsuzaki & Wataru Shihoya & Osamu Nureki, 2022. "Structure of the active Gi-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    10. Gregory Zilberg & Alexandra K. Parpounas & Audrey L. Warren & Shifan Yang & Daniel Wacker, 2024. "Molecular basis of human trace amine-associated receptor 1 activation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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