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Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

Author

Listed:
  • Russell A. Miller

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania)

  • Qingwei Chu

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania)

  • Jianxin Xie

    (Cell Signaling Technology, Inc., 3 Trask Lane, Danvers, Massachusetts 01923, USA)

  • Marc Foretz

    (Inserm, U1016, Institut Cochin
    Cnrs
    Université Paris Descartes, Sorbonne Paris cité, Paris 75006, France)

  • Benoit Viollet

    (Inserm, U1016, Institut Cochin
    Cnrs
    Université Paris Descartes, Sorbonne Paris cité, Paris 75006, France)

  • Morris J. Birnbaum

    (Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania)

Abstract

Biguanides such as metformin, which is the most widely prescribed drug for type-2 diabetes, are shown to antagonize the actions of glucagon by decreasing the levels of cyclic AMP.

Suggested Citation

  • Russell A. Miller & Qingwei Chu & Jianxin Xie & Marc Foretz & Benoit Viollet & Morris J. Birnbaum, 2013. "Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP," Nature, Nature, vol. 494(7436), pages 256-260, February.
    • Handle: RePEc:nat:nature:v:494:y:2013:i:7436:d:10.1038_nature11808
    DOI: 10.1038/nature11808
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    Cited by:

    1. Song-Yang Zhang & Tony K. T. Lam, 2022. "Metabolic regulation by the intestinal metformin-AMPK axis," Nature Communications, Nature, vol. 13(1), pages 1-3, December.
    2. Ewa Bielczyk-Maczynska & Meng Zhao & Peter-James H. Zushin & Theresia M. Schnurr & Hyun-Jung Kim & Jiehan Li & Pratima Nallagatla & Panjamaporn Sangwung & Chong Y. Park & Cameron Cornn & Andreas Stahl, 2022. "G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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