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Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

Author

Listed:
  • Peng Jiang

    (University of Pennsylvania School of Medicine)

  • Wenjing Du

    (University of Pennsylvania School of Medicine)

  • Anthony Mancuso

    (University of Pennsylvania School of Medicine)

  • Kathryn E. Wellen

    (University of Pennsylvania School of Medicine)

  • Xiaolu Yang

    (University of Pennsylvania School of Medicine)

Abstract

Evidence for a link between cellular senescence and metabolic regulation is provided, through the observation that p53 represses the expression of malic enzymes, thereby regulating NADPH, lipid and glutamine metabolism; in turn, this repression further activates p53, promoting cellular senescence.

Suggested Citation

  • Peng Jiang & Wenjing Du & Anthony Mancuso & Kathryn E. Wellen & Xiaolu Yang, 2013. "Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence," Nature, Nature, vol. 493(7434), pages 689-693, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7434:d:10.1038_nature11776
    DOI: 10.1038/nature11776
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    Cited by:

    1. Matthieu Lacroix & Laetitia K. Linares & Natalia Rueda-Rincon & Katarzyna Bloch & Michela Di Michele & Carlo De Blasio & Caroline Fau & Laurie Gayte & Emilie Blanchet & Aline Mairal & Rita Derua & Fer, 2021. "The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Alon Stern & Mariam Fokra & Boris Sarvin & Ahmad Abed Alrahem & Won Dong Lee & Elina Aizenshtein & Nikita Sarvin & Tomer Shlomi, 2023. "Inferring mitochondrial and cytosolic metabolism by coupling isotope tracing and deconvolution," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Taiqi Chen & Siyi Xie & Jie Cheng & Qiao Zhao & Hong Wu & Peng Jiang & Wenjing Du, 2024. "AKT1 phosphorylation of cytoplasmic ME2 induces a metabolic switch to glycolysis for tumorigenesis," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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