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Cytosystems dynamics in self-organization of tissue architecture

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  • Yoshiki Sasai

    (Neurogenesis and Organogenesis Group, RIKEN Center for Development Biology)

Abstract

Our knowledge of the principles by which organ architecture develops through complex collective cell behaviours is still limited. Recent work has shown that the shape of such complex tissues as the optic cup forms by self-organization in vitro from a homogeneous population of stem cells. Multicellular self-organization involves three basic processes that are crucial for the emergence of latent intrinsic order. Based on lessons from recent studies, cytosystems dynamics is proposed as a strategy for understanding collective multicellular behaviours, incorporating four-dimensional measurement, theoretical modelling and experimental reconstitution.

Suggested Citation

  • Yoshiki Sasai, 2013. "Cytosystems dynamics in self-organization of tissue architecture," Nature, Nature, vol. 493(7432), pages 318-326, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7432:d:10.1038_nature11859
    DOI: 10.1038/nature11859
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    Cited by:

    1. Elia Biganzoli & Romano Demicheli, 2021. "From Oncological Paradigms to Non-Communicable Disease Pandemic. The Need of Recovery Human Biology Evolution," IJERPH, MDPI, vol. 18(19), pages 1-6, September.
    2. Marina Sanaki-Matsumiya & Mitsuhiro Matsuda & Nicola Gritti & Fumio Nakaki & James Sharpe & Vikas Trivedi & Miki Ebisuya, 2022. "Periodic formation of epithelial somites from human pluripotent stem cells," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Guangjie Cui & Yunbo Liu & Di Zu & Xintao Zhao & Zhijia Zhang & Do Young Kim & Pramith Senaratne & Aaron Fox & David Sept & Younggeun Park & Somin Eunice Lee, 2023. "Phase intensity nanoscope (PINE) opens long-time investigation windows of living matter," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    4. Chrystian Junqueira Alves & Rafael Dariolli & Jonathan Haydak & Sangjo Kang & Theodore Hannah & Robert J. Wiener & Stefanie DeFronzo & Rut Tejero & Gabriele L. Gusella & Aarthi Ramakrishnan & Rodrigo , 2021. "Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion," Nature Communications, Nature, vol. 12(1), pages 1-23, December.

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