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Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

Author

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  • Marlen Knobloch

    (Brain Research Institute, Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland
    Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland)

  • Simon M. G. Braun

    (Brain Research Institute, Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland
    Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland)

  • Luis Zurkirchen

    (Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland)

  • Carolin von Schoultz

    (Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland)

  • Nicola Zamboni

    (Institute of Molecular Systems Biology, ETH Zurich, 8093 Zurich, Switzerland)

  • Marcos J. Araúzo-Bravo

    (Max Planck Institute for Molecular Biomedicine, 48149 Muenster, Germany)

  • Werner J. Kovacs

    (Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland)

  • Özlem Karalay

    (Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland)

  • Ueli Suter

    (Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland)

  • Raquel A. C. Machado

    (Brain Research Institute, Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland
    Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland)

  • Marta Roccio

    (Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland)

  • Matthias P. Lutolf

    (Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland)

  • Clay F. Semenkovich

    (Washington University School of Medicine, Metabolism & Lipid Research, St. Louis, Missouri 63110, USA)

  • Sebastian Jessberger

    (Brain Research Institute, Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland
    Institute of Molecular Health Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland)

Abstract

Adult neural stem and progenitor cells (NSPCs) show high levels of fatty acid synthase (Fasn)-dependent de novo lipogenesis, a process that is controlled by Spot14 to regulate the rate of proliferation; this indicates a functional coupling between the regulation of lipid metabolism and adult NSPC proliferation.

Suggested Citation

  • Marlen Knobloch & Simon M. G. Braun & Luis Zurkirchen & Carolin von Schoultz & Nicola Zamboni & Marcos J. Araúzo-Bravo & Werner J. Kovacs & Özlem Karalay & Ueli Suter & Raquel A. C. Machado & Marta Ro, 2013. "Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis," Nature, Nature, vol. 493(7431), pages 226-230, January.
    • Handle: RePEc:nat:nature:v:493:y:2013:i:7431:d:10.1038_nature11689
    DOI: 10.1038/nature11689
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    Cited by:

    1. Lily L. Wong & Christina G. Bruxvoort & Nicholas I. Cejda & Matthew R. Delaney & Jannette Rodriguez Otero & David J. Forsthoefel, 2022. "Intestine-enriched apolipoprotein b orthologs are required for stem cell progeny differentiation and regeneration in planarians," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Ting Zhao & Yan Hong & Bowen Yan & Suming Huang & Guo-li Ming & Hongjun Song, 2024. "Epigenetic maintenance of adult neural stem cell quiescence in the mouse hippocampus via Setd1a," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Sofia Madsen & Ana C. Delgado & Christelle Cadilhac & Vanille Maillard & Fabrice Battiston & Carla Marie Igelbüscher & Simon De Neck & Elia Magrinelli & Denis Jabaudon & Ludovic Telley & Fiona Doetsch, 2024. "A fluorescent perilipin 2 knock-in mouse model reveals a high abundance of lipid droplets in the developing and adult brain," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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