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A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge

Author

Listed:
  • Melissa R. Warden

    (Stanford University)

  • Aslihan Selimbeyoglu

    (Stanford University
    Neurosciences Program, Stanford University)

  • Julie J. Mirzabekov

    (Stanford University)

  • Maisie Lo

    (Bio-X Program, Stanford University)

  • Kimberly R. Thompson

    (Stanford University)

  • Sung-Yon Kim

    (Stanford University
    Neurosciences Program, Stanford University)

  • Avishek Adhikari

    (Stanford University)

  • Kay M. Tye

    (Stanford University
    Picower Institute for Learning & Memory, Massachusetts Institute of Technology)

  • Loren M. Frank

    (University of California San Francisco
    W.M. Keck Center for Integrative Neuroscience, University of California San Francisco)

  • Karl Deisseroth

    (Stanford University
    Neurosciences Program, Stanford University
    Stanford University
    CNC Program, Stanford University)

Abstract

High-speed tracking of effortful responses and neuronal activity in rats during a forced swim test identifies medial prefrontal cortex (mPFC) neurons that respond during escape-related swimming but not normal locomotion, and optogenetics shows that mPFC neurons projecting to the brainstem dorsal raphe nucleus, which is implicated in depression, modulate this behavioural response to challenge

Suggested Citation

  • Melissa R. Warden & Aslihan Selimbeyoglu & Julie J. Mirzabekov & Maisie Lo & Kimberly R. Thompson & Sung-Yon Kim & Avishek Adhikari & Kay M. Tye & Loren M. Frank & Karl Deisseroth, 2012. "A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge," Nature, Nature, vol. 492(7429), pages 428-432, December.
    • Handle: RePEc:nat:nature:v:492:y:2012:i:7429:d:10.1038_nature11617
    DOI: 10.1038/nature11617
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    Cited by:

    1. Martin Kubitschke & Monika Müller & Lutz Wallhorn & Mauro Pulin & Manuel Mittag & Stefan Pollok & Tim Ziebarth & Svenja Bremshey & Jill Gerdey & Kristin Carolin Claussen & Kim Renken & Juliana Groß & , 2022. "Next generation genetically encoded fluorescent sensors for serotonin," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Qingtao Sun & Jianping Zhang & Anan Li & Mei Yao & Guangcai Liu & Siqi Chen & Yue Luo & Zhi Wang & Hui Gong & Xiangning Li & Qingming Luo, 2022. "Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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