IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v492y2012i7429d10.1038_nature11617.html
   My bibliography  Save this article

A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge

Author

Listed:
  • Melissa R. Warden

    (Stanford University)

  • Aslihan Selimbeyoglu

    (Stanford University
    Neurosciences Program, Stanford University)

  • Julie J. Mirzabekov

    (Stanford University)

  • Maisie Lo

    (Bio-X Program, Stanford University)

  • Kimberly R. Thompson

    (Stanford University)

  • Sung-Yon Kim

    (Stanford University
    Neurosciences Program, Stanford University)

  • Avishek Adhikari

    (Stanford University)

  • Kay M. Tye

    (Stanford University
    Picower Institute for Learning & Memory, Massachusetts Institute of Technology)

  • Loren M. Frank

    (University of California San Francisco
    W.M. Keck Center for Integrative Neuroscience, University of California San Francisco)

  • Karl Deisseroth

    (Stanford University
    Neurosciences Program, Stanford University
    Stanford University
    CNC Program, Stanford University)

Abstract

High-speed tracking of effortful responses and neuronal activity in rats during a forced swim test identifies medial prefrontal cortex (mPFC) neurons that respond during escape-related swimming but not normal locomotion, and optogenetics shows that mPFC neurons projecting to the brainstem dorsal raphe nucleus, which is implicated in depression, modulate this behavioural response to challenge

Suggested Citation

  • Melissa R. Warden & Aslihan Selimbeyoglu & Julie J. Mirzabekov & Maisie Lo & Kimberly R. Thompson & Sung-Yon Kim & Avishek Adhikari & Kay M. Tye & Loren M. Frank & Karl Deisseroth, 2012. "A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge," Nature, Nature, vol. 492(7429), pages 428-432, December.
    • Handle: RePEc:nat:nature:v:492:y:2012:i:7429:d:10.1038_nature11617
    DOI: 10.1038/nature11617
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11617
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11617?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Can Tao & Guang-Wei Zhang & Wen-Jian Sun & Junxiang J. Huang & Li I. Zhang & Huizhong Whit Tao, 2024. "Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Martin Kubitschke & Monika Müller & Lutz Wallhorn & Mauro Pulin & Manuel Mittag & Stefan Pollok & Tim Ziebarth & Svenja Bremshey & Jill Gerdey & Kristin Carolin Claussen & Kim Renken & Juliana Groß & , 2022. "Next generation genetically encoded fluorescent sensors for serotonin," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Qingtao Sun & Jianping Zhang & Anan Li & Mei Yao & Guangcai Liu & Siqi Chen & Yue Luo & Zhi Wang & Hui Gong & Xiangning Li & Qingming Luo, 2022. "Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:492:y:2012:i:7429:d:10.1038_nature11617. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.