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An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis

Author

Listed:
  • Fernando Geu-Flores

    (John Innes Centre, Norwich NR4 7UH, UK)

  • Nathaniel H. Sherden

    (John Innes Centre, Norwich NR4 7UH, UK)

  • Vincent Courdavault

    (Université François-Rabelais de Tours, EA2106, Biomolécules et Biotechnologies Végétales, 37200 Tours, France)

  • Vincent Burlat

    (Université de Toulouse, UPS, UMR 5546, Laboratoire de Recherche en Sciences Végétales, BP 42617 Auzeville, F-31326 Castanet-Tolosan, France
    CNRS, UMR 5546, BP 42617, F-31326 Castanet-Tolosan, France)

  • Weslee S. Glenn

    (John Innes Centre, Norwich NR4 7UH, UK
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

  • Cen Wu

    (Michigan State University, East Lansing, Michigan 48824, USA)

  • Ezekiel Nims

    (Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Present address: Ra Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA.)

  • Yuehua Cui

    (Michigan State University, East Lansing, Michigan 48824, USA)

  • Sarah E. O’Connor

    (John Innes Centre, Norwich NR4 7UH, UK
    School of Chemistry, University of East Anglia)

Abstract

Iridoids are a large family of bicyclic natural products that possess anticancer, anti-inflammatory, antifungal and antibacterial activities; here the essential cyclization step in their biosynthesis is identified, opening up the possibility of production of naturally occurring and synthetic variants of iridoids for use in pharmacy or agriculture.

Suggested Citation

  • Fernando Geu-Flores & Nathaniel H. Sherden & Vincent Courdavault & Vincent Burlat & Weslee S. Glenn & Cen Wu & Ezekiel Nims & Yuehua Cui & Sarah E. O’Connor, 2012. "An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis," Nature, Nature, vol. 492(7427), pages 138-142, December.
    • Handle: RePEc:nat:nature:v:492:y:2012:i:7427:d:10.1038_nature11692
    DOI: 10.1038/nature11692
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    Cited by:

    1. Zhong Li & Lilan Zhang & Kangwei Xu & Yuanyuan Jiang & Jieke Du & Xingwang Zhang & Ling-Hong Meng & Qile Wu & Lei Du & Xiaoju Li & Yuechan Hu & Zhenzhen Xie & Xukai Jiang & Ya-Jie Tang & Ruibo Wu & Re, 2023. "Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Néstor J. Hernández Lozada & Benke Hong & Joshua C. Wood & Lorenzo Caputi & Jérôme Basquin & Ling Chuang & Maritta Kunert & Carlos E. Rodríguez López & Chloe Langley & Dongyan Zhao & C. Robin Buell & , 2022. "Biocatalytic routes to stereo-divergent iridoids," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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