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B12 cofactors directly stabilize an mRNA regulatory switch

Author

Listed:
  • James E. Johnson Jr

    (University of Colorado at Boulder, UCB 596, Boulder, Colorado 80309-0596, USA)

  • Francis E. Reyes

    (University of Colorado at Boulder, UCB 596, Boulder, Colorado 80309-0596, USA
    Present address: Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.)

  • Jacob T. Polaski

    (University of Colorado at Boulder, UCB 596, Boulder, Colorado 80309-0596, USA)

  • Robert T. Batey

    (University of Colorado at Boulder, UCB 596, Boulder, Colorado 80309-0596, USA)

Abstract

The crystal structures of two different cobalamin (vitamin B12)-binding riboswitches are determined; the structures reveal how cobalamin facilitates interdomain interactions to regulate gene expression.

Suggested Citation

  • James E. Johnson Jr & Francis E. Reyes & Jacob T. Polaski & Robert T. Batey, 2012. "B12 cofactors directly stabilize an mRNA regulatory switch," Nature, Nature, vol. 492(7427), pages 133-137, December.
    • Handle: RePEc:nat:nature:v:492:y:2012:i:7427:d:10.1038_nature11607
    DOI: 10.1038/nature11607
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    Cited by:

    1. Jienyu Ding & Yun-Tzai Lee & Yuba Bhandari & Charles D. Schwieters & Lixin Fan & Ping Yu & Sergey G. Tarosov & Jason R. Stagno & Buyong Ma & Ruth Nussinov & Alan Rein & Jinwei Zhang & Yun-Xing Wang, 2023. "Visualizing RNA conformational and architectural heterogeneity in solution," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Shaifaly Parmar & Desta Doro Bume & Colleen M. Connelly & Robert E. Boer & Peri R. Prestwood & Zhen Wang & Henning Labuhn & Krishshanthi Sinnadurai & Adeline Feri & Jimmy Ouellet & Philip Homan & Tomo, 2024. "Mechanistic analysis of Riboswitch Ligand interactions provides insights into pharmacological control over gene expression," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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