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Structure and function of Zucchini endoribonuclease in piRNA biogenesis

Author

Listed:
  • Hiroshi Nishimasu

    (Graduate School of Science, The University of Tokyo)

  • Hirotsugu Ishizu

    (Graduate School of Science, The University of Tokyo
    Keio University School of Medicine)

  • Kuniaki Saito

    (Keio University School of Medicine)

  • Satoshi Fukuhara

    (Graduate School of Science, The University of Tokyo)

  • Miharu K. Kamatani

    (Keio University School of Medicine)

  • Luc Bonnefond

    (Graduate School of Science, The University of Tokyo
    Present address: Institut de Génétique et de Biologie Moléculaire et Cellulaire, UMR7104 CNRS-UDS, INSERM U964, 1 rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France.)

  • Naoki Matsumoto

    (Graduate School of Science, The University of Tokyo)

  • Tomohiro Nishizawa

    (Graduate School of Science, The University of Tokyo)

  • Keita Nakanaga

    (Graduate School of Pharmaceutical Sciences, Tohoku University)

  • Junken Aoki

    (Graduate School of Pharmaceutical Sciences, Tohoku University)

  • Ryuichiro Ishitani

    (Graduate School of Science, The University of Tokyo)

  • Haruhiko Siomi

    (Keio University School of Medicine)

  • Mikiko C. Siomi

    (Graduate School of Science, The University of Tokyo
    Keio University School of Medicine
    Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST))

  • Osamu Nureki

    (Graduate School of Science, The University of Tokyo
    Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST))

Abstract

Zucchini has been identified as an endoribonuclease responsible for the maturation of small RNA molecules that protect the genome from the damaging effects of unrestrained expression of mobile elements.

Suggested Citation

  • Hiroshi Nishimasu & Hirotsugu Ishizu & Kuniaki Saito & Satoshi Fukuhara & Miharu K. Kamatani & Luc Bonnefond & Naoki Matsumoto & Tomohiro Nishizawa & Keita Nakanaga & Junken Aoki & Ryuichiro Ishitani , 2012. "Structure and function of Zucchini endoribonuclease in piRNA biogenesis," Nature, Nature, vol. 491(7423), pages 284-287, November.
    • Handle: RePEc:nat:nature:v:491:y:2012:i:7423:d:10.1038_nature11509
    DOI: 10.1038/nature11509
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    Cited by:

    1. Yu H. Sun & Ruoqiao Huiyi Wang & Khai Du & Jiang Zhu & Jihong Zheng & Li Huitong Xie & Amanda A. Pereira & Chao Zhang & Emiliano P. Ricci & Xin Zhiguo Li, 2021. "Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    2. Susanne Bornelöv & Benjamin Czech & Gregory J. Hannon, 2022. "An evolutionarily conserved stop codon enrichment at the 5′ ends of mammalian piRNAs," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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