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BATF–JUN is critical for IRF4-mediated transcription in T cells

Author

Listed:
  • Peng Li

    (Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Rosanne Spolski

    (Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Wei Liao

    (Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Lu Wang

    (Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Theresa L. Murphy

    (Washington University School of Medicine)

  • Kenneth M. Murphy

    (Washington University School of Medicine
    Howard Hughes Medical Institute, Washington University School of Medicine)

  • Warren J. Leonard

    (Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health)

Abstract

The pleiotropic transcription factor IRF4 is shown to regulate CD4+ T-cell differentiation and TH17 function through cooperative binding interactions with BATF and JUN family proteins via AP1–IRF4 composite elements (AICEs).

Suggested Citation

  • Peng Li & Rosanne Spolski & Wei Liao & Lu Wang & Theresa L. Murphy & Kenneth M. Murphy & Warren J. Leonard, 2012. "BATF–JUN is critical for IRF4-mediated transcription in T cells," Nature, Nature, vol. 490(7421), pages 543-546, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7421:d:10.1038_nature11530
    DOI: 10.1038/nature11530
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    Cited by:

    1. Gil-Woo Lee & Young Ju Kim & Sung-Woo Lee & Hee-Ok Kim & Daeun Kim & Jiyoung Kim & You-Me Kim & Keunsoo Kang & Joon Haeng Rhee & Ik Joo Chung & Woo Kyun Bae & In-Jae Oh & Deok Hwan Yang & Jae-Ho Cho, 2024. "Developmental self-reactivity determines pathogenic Tc17 differentiation potential of naive CD8+ T cells in murine models of inflammation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Nikolai Schleussner & Pierre Cauchy & Vedran Franke & Maciej Giefing & Oriol Fornes & Naveen Vankadari & Salam A. Assi & Mariantonia Costanza & Marc A. Weniger & Altuna Akalin & Ioannis Anagnostopoulo, 2023. "Transcriptional reprogramming by mutated IRF4 in lymphoma," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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