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Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

Author

Listed:
  • Mi Sun Jin

    (Purdue University)

  • Michael L. Oldham

    (Howard Hughes Medical Institute)

  • Qiuju Zhang

    (Howard Hughes Medical Institute)

  • Jue Chen

    (Purdue University
    Howard Hughes Medical Institute)

Abstract

Biochemical and structural analysis of the drug transporter P-glycoprotein in Caenorhabditis elegans at a resolution of 3.4 angstroms is used to generate a homology model of the human protein and supports a picture in which P-glycoprotein uses the energy from ATP hydrolysis to expel lipophilic molecules from the inner leaflet of the cell membrane.

Suggested Citation

  • Mi Sun Jin & Michael L. Oldham & Qiuju Zhang & Jue Chen, 2012. "Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans," Nature, Nature, vol. 490(7421), pages 566-569, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7421:d:10.1038_nature11448
    DOI: 10.1038/nature11448
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    Cited by:

    1. Jun Gyou Park & Songwon Kim & Eunhong Jang & Seung Hun Choi & Hyunsu Han & Seulgi Ju & Ji Won Kim & Da Sol Min & Mi Sun Jin, 2022. "The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Qingyu Tang & Matt Sinclair & Hale S. Hasdemir & Richard A. Stein & Erkan Karakas & Emad Tajkhorshid & Hassane S. Mchaourab, 2023. "Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Yao-Xu Mao & Zhi-Peng Chen & Liang Wang & Jie Wang & Cong-Zhao Zhou & Wen-Tao Hou & Yuxing Chen, 2024. "Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    4. Megan L O’Mara & Alan E Mark, 2014. "Structural Characterization of Two Metastable ATP-Bound States of P-Glycoprotein," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-14, March.

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