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Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

Author

Listed:
  • Morgane Rolland

    (US Military HIV Research Program)

  • Paul T. Edlefsen

    (Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center)

  • Brendan B. Larsen

    (University of Washington)

  • Sodsai Tovanabutra

    (US Military HIV Research Program)

  • Eric Sanders-Buell

    (US Military HIV Research Program)

  • Tomer Hertz

    (Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center)

  • Allan C. deCamp

    (Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center)

  • Chris Carrico

    (University of Washington
    The Scripps Research Institute)

  • Sergey Menis

    (University of Washington
    The Scripps Research Institute)

  • Craig A. Magaret

    (Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center)

  • Hasan Ahmed

    (Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center)

  • Michal Juraska

    (Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center)

  • Lennie Chen

    (University of Washington)

  • Philip Konopa

    (University of Washington)

  • Snehal Nariya

    (University of Washington)

  • Julia N. Stoddard

    (University of Washington)

  • Kim Wong

    (University of Washington)

  • Hong Zhao

    (University of Washington)

  • Wenjie Deng

    (University of Washington)

  • Brandon S. Maust

    (University of Washington)

  • Meera Bose

    (US Military HIV Research Program)

  • Shana Howell

    (US Military HIV Research Program)

  • Adam Bates

    (US Military HIV Research Program)

  • Michelle Lazzaro

    (US Military HIV Research Program)

  • Annemarie O’Sullivan

    (US Military HIV Research Program)

  • Esther Lei

    (US Military HIV Research Program)

  • Andrea Bradfield

    (US Military HIV Research Program)

  • Grace Ibitamuno

    (US Military HIV Research Program)

  • Vatcharain Assawadarachai

    (Royal Thai Army Component, AFRIMS, Bangkok 10400, Thailand)

  • Robert J. O’Connell

    (US Military HIV Research Program)

  • Mark S. deSouza

    (Royal Thai Army Component, AFRIMS, Bangkok 10400, Thailand)

  • Sorachai Nitayaphan

    (Royal Thai Army Component, AFRIMS, Bangkok 10400, Thailand)

  • Supachai Rerks-Ngarm

    (Thai Ministry of Public Health, Nonthaburi 11000, Thailand)

  • Merlin L. Robb

    (US Military HIV Research Program)

  • Jason S. McLellan

    (Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Ivelin Georgiev

    (Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Peter D. Kwong

    (Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA)

  • Jonathan M. Carlson

    (Microsoft Research)

  • Nelson L. Michael

    (US Military HIV Research Program)

  • William R. Schief

    (University of Washington
    The Scripps Research Institute)

  • Peter B. Gilbert

    (Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center)

  • James I. Mullins

    (University of Washington)

  • Jerome H. Kim

    (US Military HIV Research Program)

Abstract

Genetic analysis of breakthrough infections in people vaccinated against HIV-1 show that vaccine efficacy increased by up to 80% against viruses carrying two mutations in Env V2, but also raises the possibility of population-level adaptation to the vaccine.

Suggested Citation

  • Morgane Rolland & Paul T. Edlefsen & Brendan B. Larsen & Sodsai Tovanabutra & Eric Sanders-Buell & Tomer Hertz & Allan C. deCamp & Chris Carrico & Sergey Menis & Craig A. Magaret & Hasan Ahmed & Micha, 2012. "Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2," Nature, Nature, vol. 490(7420), pages 417-420, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7420:d:10.1038_nature11519
    DOI: 10.1038/nature11519
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    Cited by:

    1. Svenja Weiss & Vincenza Itri & Ruimin Pan & Xunqing Jiang & Christina C. Luo & Lynn Morris & Delphine C. Malherbe & Philip Barnette & Jeff Alexander & Xiang-Peng Kong & Nancy L. Haigwood & Ann J. Hess, 2022. "Differential V2-directed antibody responses in non-human primates infected with SHIVs or immunized with diverse HIV vaccines," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Jeffy G. Mattathil & Asisa Volz & Olusegun O. Onabajo & Sean Maynard & Sandra L. Bixler & Xiaoying X. Shen & Diego Vargas-Inchaustegui & Marjorie Robert-Guroff & Celia Lebranche & Georgia Tomaras & Da, 2023. "Direct intranodal tonsil vaccination with modified vaccinia Ankara vaccine protects macaques from highly pathogenic SIVmac251," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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