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Nonlinear dendritic processing determines angular tuning of barrel cortex neurons in vivo

Author

Listed:
  • Maria Lavzin

    (the Rappaport Faculty of Medicine & Research Institute, Technion-Israel Institute of Technology, Bat-Galim, Haifa 31096, Israel)

  • Sophia Rapoport

    (the Rappaport Faculty of Medicine & Research Institute, Technion-Israel Institute of Technology, Bat-Galim, Haifa 31096, Israel)

  • Alon Polsky

    (Synaptic Physiology Section, National Institute of Neurological Disorders & Stroke. National Institutes of Health)

  • Liora Garion

    (the Rappaport Faculty of Medicine & Research Institute, Technion-Israel Institute of Technology, Bat-Galim, Haifa 31096, Israel)

  • Jackie Schiller

    (the Rappaport Faculty of Medicine & Research Institute, Technion-Israel Institute of Technology, Bat-Galim, Haifa 31096, Israel)

Abstract

In vivo whole-cell recordings combined with an intracellular N-methyl-d-aspartate receptor (NMDAR) blocker and membrane hyperpolarization are used to examine the contribution of dendritic NMDAR-dependent regenerative responses to the angular tuning of layer 4 neurons; the results show that active dendritic processing sharpens the sensory responses of cortical neurons in vivo.

Suggested Citation

  • Maria Lavzin & Sophia Rapoport & Alon Polsky & Liora Garion & Jackie Schiller, 2012. "Nonlinear dendritic processing determines angular tuning of barrel cortex neurons in vivo," Nature, Nature, vol. 490(7420), pages 397-401, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7420:d:10.1038_nature11451
    DOI: 10.1038/nature11451
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    Cited by:

    1. Hang Zhou & Guo-Qiang Bi & Guosong Liu, 2024. "Intracellular magnesium optimizes transmission efficiency and plasticity of hippocampal synapses by reconfiguring their connectivity," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Matteo Farinella & Daniel T Ruedt & Padraig Gleeson & Frederic Lanore & R Angus Silver, 2014. "Glutamate-Bound NMDARs Arising from In Vivo-like Network Activity Extend Spatio-temporal Integration in a L5 Cortical Pyramidal Cell Model," PLOS Computational Biology, Public Library of Science, vol. 10(4), pages 1-21, April.

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