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FTO genotype is associated with phenotypic variability of body mass index

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Listed:
  • Jian Yang

    (University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia.
    Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia.)

  • Ruth J. F. Loos

    (MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
    Mount Sinai School of Medicine)

  • Joseph E. Powell

    (University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia.
    Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia.)

  • Sarah E. Medland

    (Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia.)

  • Elizabeth K. Speliotes

    (University of Michigan, Ann Arbor, Michigan 48109, USA.
    Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.)

  • Daniel I. Chasman

    (Brigham and Women’s Hospital, 900 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
    Harvard Medical School)

  • Lynda M. Rose

    (Brigham and Women’s Hospital, 900 Commonwealth Avenue, Boston, Massachusetts 02215, USA.)

  • Gudmar Thorleifsson

    (deCODE genetics, IS-101 Reykjavik, Iceland.)

  • Valgerdur Steinthorsdottir

    (deCODE genetics, IS-101 Reykjavik, Iceland.)

  • Reedik Mägi

    (Estonian Genome Center, University of Tartu, Tartu 50410, Estonia.
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.)

  • Lindsay Waite

    (Hudson Alpha Institute for Biotechnology)

  • Albert Vernon Smith

    (Icelandic Heart Association, IS-201 Kopavogur, Iceland.
    University of Iceland, IS-101 Reykjavik, Iceland.)

  • Laura M. Yerges-Armstrong

    (University of Maryland School of Medicine)

  • Keri L. Monda

    (The University of North Carolina)

  • David Hadley

    (St George’s, University of London, London SW17 0RE, UK.)

  • Anubha Mahajan

    (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.)

  • Guo Li

    (Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA.)

  • Karen Kapur

    (University of Lausanne, 1005 Lausanne, Switzerland.
    Swiss Institute of Bioinformatics, 1005 Lausanne, Switzerland.)

  • Veronique Vitart

    (MRC HGU at the MRC IGMM at the University of Edinburgh, Edinburgh EH8 9AG, UK.)

  • Jennifer E. Huffman

    (MRC HGU at the MRC IGMM at the University of Edinburgh, Edinburgh EH8 9AG, UK.)

  • Sophie R. Wang

    (Harvard Medical School
    Children’s Hospital, Boston, Massachusetts 02115, USA.
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.)

  • Cameron Palmer

    (Children’s Hospital, Boston, Massachusetts 02115, USA.
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.)

  • Tõnu Esko

    (Estonian Genome Center, University of Tartu, Tartu 50410, Estonia.)

  • Krista Fischer

    (Estonian Genome Center, University of Tartu, Tartu 50410, Estonia.)

  • Jing Hua Zhao

    (MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.)

  • Ayşe Demirkan

    (Subdivison Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands.)

  • Aaron Isaacs

    (Subdivison Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands.)

  • Mary F. Feitosa

    (Washington University School of Medicine, St Louis, Missouri 63110, USA.)

  • Jian’an Luan

    (MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.)

  • Nancy L. Heard-Costa

    (Boston University)

  • Charles White

    (Boston University)

  • Anne U. Jackson

    (University of Michigan, Ann Arbor, Michigan 48109, USA.)

  • Michael Preuss

    (Universität zu Lübeck, Medizinische Klinik II, Ratzeburger Allee 160, 23538 Lübeck, Germany.
    Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, 23562 Lübeck, Germany.)

  • Andreas Ziegler

    (Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, 23562 Lübeck, Germany.)

  • Joel Eriksson

    (Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.)

  • Zoltán Kutalik

    (University of Lausanne, 1005 Lausanne, Switzerland.
    Swiss Institute of Bioinformatics, 1005 Lausanne, Switzerland.)

  • Francesca Frau

    (University of Milano, 20133 Milano, Italy.)

  • Ilja M. Nolte

    (Unit of Genetic Epidemiology & Bioinformatics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.)

  • Jana V. Van Vliet-Ostaptchouk

    (University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands.
    LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.)

  • Jouke-Jan Hottenga

    (VU University, 1081 BT Amsterdam, The Netherlands.)

  • Kevin B. Jacobs

    (Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA.)

  • Niek Verweij

    (University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.)

  • Anuj Goel

    (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
    Cardiovascular Medicine, University of Oxford, Oxford OX3 7BN, UK.)

  • Carolina Medina-Gomez

    (Erasmus MC, Rotterdam 3015GE, The Netherlands.
    Erasmus MC, Rotterdam 3015GE, The Netherlands.
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), 2300 RC Leiden, The Netherlands.)

  • Karol Estrada

    (Erasmus MC, Rotterdam 3015GE, The Netherlands.
    Erasmus MC, Rotterdam 3015GE, The Netherlands.
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), 2300 RC Leiden, The Netherlands.)

  • Jennifer Lynn Bragg-Gresham

    (Biostatistics - Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.)

  • Serena Sanna

    (Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato 09042, Italy.)

  • Carlo Sidore

    (Biostatistics - Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
    Università di Sassari, 07100 SS, Italy.)

  • Jonathan Tyrer

    (University of Cambridge, Cambridge CB1 8RN, UK.)

  • Alexander Teumer

    (Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17487 Greifswald, Germany.)

  • Inga Prokopenko

    (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7BN, UK.)

  • Massimo Mangino

    (King’s College London, Lambeth Palace Road, London SE1 7EH, UK.)

  • Cecilia M. Lindgren

    (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.)

  • Themistocles L. Assimes

    (Stanford University School of Medicine, Stanford 94305, California, USA.)

  • Alan R. Shuldiner

    (University of Maryland School of Medicine
    Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland 21201, USA.)

  • Jennie Hui

    (Pathology and Laboratory Medicine, University of Western Australia, Nedlands Western Australia 6009, Australia.
    Molecular Genetics, PathWest Laboratory Medicine WA, University of Western Australia, Nedlands Western Australia 6009, Australia.
    School of Population Health, University of Western Australia, Nedlands Western Australia 6009, Australia.)

  • John P. Beilby

    (Pathology and Laboratory Medicine, University of Western Australia, Nedlands Western Australia 6009, Australia.
    Molecular Genetics, PathWest Laboratory Medicine WA, University of Western Australia, Nedlands Western Australia 6009, Australia.)

  • Wendy L. McArdle

    (School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.)

  • Per Hall

    (Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden.)

  • Talin Haritunians

    (Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.)

  • Lina Zgaga

    (Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh EH16 4TJ, UK.
    Andrija Stampar School of Public Health, Medical School University of Zagreb)

  • Ivana Kolcic

    (Faculty of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia.)

  • Ozren Polasek

    (Faculty of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia.)

  • Tatijana Zemunik

    (Faculty of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia.)

  • Ben A. Oostra

    (Subdivison Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands.)

  • M. Juhani Junttila

    (Institute of Clinical Medicine, University of Oulu, 90014 Oulu, Finland.)

  • Henrik Grönberg

    (Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden.)

  • Stefan Schreiber

    (Institut für Klinische Molekularbiologie, Christian-Albrechts Universität, 24098 Kiel, Germany.)

  • Annette Peters

    (Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
    Munich Heart Alliance, 80802 Munich, Germany.)

  • Andrew A. Hicks

    (Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy.)

  • Jonathan Stephens

    (University of Cambridge, Cambridge CB2 0PT, UK.
    NHS Blood and Transplant, Cambridge, Cambridge CB2 0PT, UK.)

  • Nicola S. Foad

    (University of Cambridge, Cambridge CB2 0PT, UK.
    NHS Blood and Transplant, Cambridge, Cambridge CB2 0PT, UK.)

  • Jaana Laitinen

    (Finnish Institute of Occupational Health, 90220 Oulu, Finland.)

  • Anneli Pouta

    (National Institute for Health and Welfare, 90101 Oulu, Finland.
    University of Oulu, 90014 Oulu, Finland.)

  • Marika Kaakinen

    (Institute of Health Sciences, Biocenter Oulu, University of Oulu, 90014 Oulu, Finland.)

  • Gonneke Willemsen

    (VU University, 1081 BT Amsterdam, The Netherlands.)

  • Jacqueline M. Vink

    (VU University, 1081 BT Amsterdam, The Netherlands.)

  • Sarah H. Wild

    (Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh EH16 4TJ, UK.)

  • Gerjan Navis

    (University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.)

  • Folkert W. Asselbergs

    (University medical Center Utrecht, 3508 GA Utrecht, The Netherlands.)

  • Georg Homuth

    (Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17487 Greifswald, Germany.)

  • Ulrich John

    (Institute of Epidemiology and Social Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.)

  • Carlos Iribarren

    (Kaiser Permanente Northern California)

  • Tamara Harris

    (National Institutes on Aging, National Institutes of Health)

  • Lenore Launer

    (National Institutes on Aging, National Institutes of Health)

  • Vilmundur Gudnason

    (Icelandic Heart Association, IS-201 Kopavogur, Iceland.
    University of Iceland, IS-101 Reykjavik, Iceland.)

  • Jeffrey R. O’Connell

    (University of Maryland School of Medicine)

  • Eric Boerwinkle

    (The University of Texas Health Science Centers)

  • Gemma Cadby

    (Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario M5G 1L7, Canada.)

  • Lyle J. Palmer

    (Genetic Epidemiology and Biostatistics Platform, Ontario Institute for Cancer Research, Toronto, Ontario M5G 1L7, Canada.)

  • Alan L. James

    (Medicine and Pharmacology, University of Western Australia, Nedlands Western Australia 6009, Australia.
    Pulmonary Physiology, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands Western Australia 6009, Australia.)

  • Arthur W. Musk

    (Medicine and Pharmacology, University of Western Australia, Nedlands Western Australia 6009, Australia.
    Respiratory Medicine, Sir Charles Gairdner Hospital, University of Western Australia, Nedlands Western Australia 6009, Australia.)

  • Erik Ingelsson

    (Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden.)

  • Bruce M. Psaty

    (Cardiovascular Health Research Unit, Epidemiology, and Health Services, University of Washington, Seattle, Washington 98101, USA.
    Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA.)

  • Jacques S. Beckmann

    (University of Lausanne, 1005 Lausanne, Switzerland.
    Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, 1011 Lausanne, Switzerland.)

  • Gerard Waeber

    (University Hospital, 1011 Lausanne, Switzerland.)

  • Peter Vollenweider

    (University Hospital, 1011 Lausanne, Switzerland.)

  • Caroline Hayward

    (MRC HGU at the MRC IGMM at the University of Edinburgh, Edinburgh EH8 9AG, UK.)

  • Alan F. Wright

    (MRC HGU at the MRC IGMM at the University of Edinburgh, Edinburgh EH8 9AG, UK.)

  • Igor Rudan

    (Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh EH16 4TJ, UK.
    Faculty of Medicine, University of Split, Soltanska 2, 21000 Split, Croatia.)

  • Leif C. Groop

    (Lund University Diabetes Centre, Lund University, 20502 Malmö, Sweden.)

  • Andres Metspalu

    (Estonian Genome Center, University of Tartu, Tartu 50410, Estonia.)

  • Kay-Tee Khaw

    (University of Cambridge, Cambridge CB1 8RN, UK.)

  • Cornelia M. van Duijn

    (Subdivison Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands.)

  • Ingrid B. Borecki

    (Washington University School of Medicine, St Louis, Missouri 63110, USA.)

  • Michael A. Province

    (Washington University School of Medicine, St Louis, Missouri 63110, USA.)

  • Nicholas J. Wareham

    (MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.)

  • Jean-Claude Tardif

    (Université de Montréal, Montréal, Québec H4J 1C5, Canada.
    Montreal Heart Institute, Montréal, Québec H1T 1C8, Canada.)

  • Heikki V. Huikuri

    (Institute of Clinical Medicine, University of Oulu, 90014 Oulu, Finland.)

  • L. Adrienne Cupples

    (Boston University
    Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts 01702, USA.)

  • Larry D. Atwood

    (Boston University)

  • Caroline S. Fox

    (Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts 01702, USA.)

  • Michael Boehnke

    (University of Michigan, Ann Arbor, Michigan 48109, USA.)

  • Francis S. Collins

    (National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.)

  • Karen L. Mohlke

    (University of North Carolina)

  • Jeanette Erdmann

    (Universität zu Lübeck, Medizinische Klinik II, Ratzeburger Allee 160, 23538 Lübeck, Germany.
    Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Universität zu Lübeck, 23562 Lübeck, Germany.)

  • Heribert Schunkert

    (Universität zu Lübeck, Medizinische Klinik II, Ratzeburger Allee 160, 23538 Lübeck, Germany.
    Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Universität zu Lübeck, 23562 Lübeck, Germany.)

  • Christian Hengstenberg

    (Klinik und Poliklinik für Innere Medizin II, 93053 Regensburg, Germany.)

  • Klaus Stark

    (Klinik und Poliklinik für Innere Medizin II, 93053 Regensburg, Germany.)

  • Mattias Lorentzon

    (Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.)

  • Claes Ohlsson

    (Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.)

  • Daniele Cusi

    (University of Milano, 20133 Milano, Italy.)

  • Jan A. Staessen

    (University of Leuven, 3000 Leuven, Belgium.
    Maastricht University, 6200 MD Maastricht, The Netherlands.)

  • Melanie M. Van der Klauw

    (University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands.
    LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.)

  • Peter P. Pramstaller

    (Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy.
    General Central Hospital, 39100 Bolzano, Italy.
    University of Lübeck, 23562 Lübeck, Germany.)

  • Sekar Kathiresan

    (Framingham Heart Study of the National Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts 01702, USA.
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
    Center for Human Genetics Research, Massachusetts General Hospital
    Massachusetts General Hospital)

  • Jennifer D. Jolley

    (University of Cambridge, Cambridge CB2 0PT, UK.
    NHS Blood and Transplant, Cambridge, Cambridge CB2 0PT, UK.)

  • Samuli Ripatti

    (Institute for Molecular Medicine Finland, FIMM, University of Helsinki, 00014 Helsinki, Finland.
    Public Health Genomics Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland.
    Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.)

  • Marjo-Riitta Jarvelin

    (National Institute for Health and Welfare, 90101 Oulu, Finland.
    Institute of Health Sciences, Biocenter Oulu, University of Oulu, 90014 Oulu, Finland.
    MRC-HPA Center for Environment and Health, Imperial College London, London W2 1PG, UK.)

  • Eco J. C. de Geus

    (VU University, 1081 BT Amsterdam, The Netherlands.)

  • Dorret I. Boomsma

    (VU University, 1081 BT Amsterdam, The Netherlands.)

  • Brenda Penninx

    (University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.)

  • James F. Wilson

    (Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh EH16 4TJ, UK.)

  • Harry Campbell

    (Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh EH16 4TJ, UK.)

  • Stephen J. Chanock

    (National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA.)

  • Pim van der Harst

    (University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.)

  • Anders Hamsten

    (Karolinska Institutet, 171 77 Stockholm, Sweden.
    Atherosclerosis Research Unit, Solna, 171 76 Stockholm, Sweden.)

  • Hugh Watkins

    (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
    Cardiovascular Medicine, University of Oxford, Oxford OX3 7BN, UK.)

  • Albert Hofman

    (Erasmus MC, Rotterdam 3015GE, The Netherlands.
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), 2300 RC Leiden, The Netherlands.)

  • Jacqueline C. Witteman

    (Erasmus MC, Rotterdam 3015GE, The Netherlands.
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), 2300 RC Leiden, The Netherlands.)

  • M. Carola Zillikens

    (Erasmus MC, Rotterdam 3015GE, The Netherlands.)

  • André G. Uitterlinden

    (Erasmus MC, Rotterdam 3015GE, The Netherlands.
    Erasmus MC, Rotterdam 3015GE, The Netherlands.
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), 2300 RC Leiden, The Netherlands.)

  • Fernando Rivadeneira

    (Erasmus MC, Rotterdam 3015GE, The Netherlands.
    Erasmus MC, Rotterdam 3015GE, The Netherlands.
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), 2300 RC Leiden, The Netherlands.)

  • M. Carola Zillikens

    (Erasmus MC, Rotterdam 3015GE, The Netherlands.)

  • Lambertus A. Kiemeney

    (Epidemiology, Biostatistics & HTA, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.)

  • Sita H. Vermeulen

    (Epidemiology, Biostatistics & HTA, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.)

  • Goncalo R. Abecasis

    (Biostatistics - Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.)

  • David Schlessinger

    (National Institute on Aging, National Institutes of Health)

  • Sabine Schipf

    (Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.)

  • Michael Stumvoll

    (University of Leipzig, 04103 Leipzig, Germany.
    IFB Adiposity Diseases, University of Leipzig, 04103 Leipzig, Germany.)

  • Anke Tönjes

    (University of Leipzig, 04103 Leipzig, Germany.
    IFB Adiposity Diseases, University of Leipzig, 04103 Leipzig, Germany.)

  • Tim D. Spector

    (King’s College London, Lambeth Palace Road, London SE1 7EH, UK.)

  • Kari E. North

    (The University of North Carolina, Chapel Hill, North Carolina 27514, USA.)

  • Guillaume Lettre

    (Université de Montréal, Montréal, Québec H4J 1C5, Canada.
    Montreal Heart Institute, Montréal, Québec H1T 1C8, Canada.)

  • Mark I. McCarthy

    (Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7BN, UK.
    Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Old Road Headington, Oxford OX3 7LJ, UK.)

  • Sonja I. Berndt

    (National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA.)

  • Andrew C. Heath

    (Washington University St Louis)

  • Pamela A. F. Madden

    (Washington University St Louis)

  • Dale R. Nyholt

    (Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia.)

  • Grant W. Montgomery

    (Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia.)

  • Nicholas G. Martin

    (Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia.)

  • Barbara McKnight

    (University of Washington)

  • David P. Strachan

    (St George’s, University of London, London SW17 0RE, UK.)

  • William G. Hill

    (Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK.)

  • Harold Snieder

    (Unit of Genetic Epidemiology & Bioinformatics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
    LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.)

  • Paul M. Ridker

    (Brigham and Women’s Hospital, 900 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
    Harvard Medical School)

  • Unnur Thorsteinsdottir

    (deCODE genetics, IS-101 Reykjavik, Iceland.
    Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.)

  • Kari Stefansson

    (deCODE genetics, IS-101 Reykjavik, Iceland.
    Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.)

  • Timothy M. Frayling

    (Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, University of Exeter, Exeter EX1 2LU, UK.)

  • Joel N. Hirschhorn

    (Harvard Medical School
    Children’s Hospital, Boston, Massachusetts 02115, USA.
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.)

  • Michael E. Goddard

    (University of Melbourne, Victoria 3010, Australia.
    Bundoora, Victoria 3083, Australia.)

  • Peter M. Visscher

    (University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia.
    Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4006, Australia.
    Queensland Brain Institute, The University of Queensland)

Abstract

A meta-analysis of genome-wide association studies of phenotypic variation for height and body mass index in human populations using 170,000 samples shows that one single nucleotide polymorphism at the FTO locus, which is associated with obesity, is also associated with phenotypic variation.

Suggested Citation

  • Jian Yang & Ruth J. F. Loos & Joseph E. Powell & Sarah E. Medland & Elizabeth K. Speliotes & Daniel I. Chasman & Lynda M. Rose & Gudmar Thorleifsson & Valgerdur Steinthorsdottir & Reedik Mägi & Lindsa, 2012. "FTO genotype is associated with phenotypic variability of body mass index," Nature, Nature, vol. 490(7419), pages 267-272, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7419:d:10.1038_nature11401
    DOI: 10.1038/nature11401
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    Cited by:

    1. Meghana Pagadala & Timothy J. Sears & Victoria H. Wu & Eva Pérez-Guijarro & Hyo Kim & Andrea Castro & James V. Talwar & Cristian Gonzalez-Colin & Steven Cao & Benjamin J. Schmiedel & Shervin Goudarzi , 2023. "Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Robert F. Hillary & Danni A. Gadd & Zhana Kuncheva & Tasos Mangelis & Tinchi Lin & Kyle Ferber & Helen McLaughlin & Heiko Runz & Riccardo E. Marioni & Christopher N. Foley & Benjamin B. Sun, 2024. "Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK Biobank," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Kathryn E. Kemper & Julia Sidorenko & Huanwei Wang & Ben J. Hayes & Naomi R. Wray & Loic Yengo & Matthew C. Keller & Michael Goddard & Peter M. Visscher, 2024. "Genetic influence on within-person longitudinal change in anthropometric traits in the UK Biobank," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Chen-Cheng Yang & Chia-Yen Dai & Kuei-Hau Luo & Kuo-Wei Lee & Cheng-Hang Wu & Chih-Hsing Hung & Hung-Yi Chuang & Chao-Hung Kuo, 2022. "Single Nucleotide Polymorphism of TWIST2 May Be a Modifier for the Association between High-Density Lipoprotein Cholesterol and Blood Lead (Pb) Level," IJERPH, MDPI, vol. 19(3), pages 1-10, January.
    5. Kenneth E. Westerman & Timothy D. Majarian & Franco Giulianini & Dong-Keun Jang & Jenkai Miao & Jose C. Florez & Han Chen & Daniel I. Chasman & Miriam S. Udler & Alisa K. Manning & Joanne B. Cole, 2022. "Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    6. Chen Wang & Tianying Wang & Krzysztof Kiryluk & Ying Wei & Hugues Aschard & Iuliana Ionita-Laza, 2024. "Genome-wide discovery for biomarkers using quantile regression at biobank scale," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    7. James P. Pirruccello & Paolo Achille & Seung Hoan Choi & Joel T. Rämö & Shaan Khurshid & Mahan Nekoui & Sean J. Jurgens & Victor Nauffal & Shinwan Kany & Kenney Ng & Samuel F. Friedman & Puneet Batra , 2024. "Deep learning of left atrial structure and function provides link to atrial fibrillation risk," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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