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Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function

Author

Listed:
  • Juan I. Garaycoechea

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Gerry P. Crossan

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Frederic Langevin

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Maria Daly

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Mark J. Arends

    (University of Cambridge, Addenbrooke’s Hospital)

  • Ketan J. Patel

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    University of Cambridge, Level 5, Addenbrooke’s Hospital)

Abstract

The function of haematopoietic stem and progenitor cells is impaired by damaged DNA; here, endogenously generated aldehydes are found to be one source of such damage, which is repaired by the Fanconi anaemia pathway.

Suggested Citation

  • Juan I. Garaycoechea & Gerry P. Crossan & Frederic Langevin & Maria Daly & Mark J. Arends & Ketan J. Patel, 2012. "Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function," Nature, Nature, vol. 489(7417), pages 571-575, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7417:d:10.1038_nature11368
    DOI: 10.1038/nature11368
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    Cited by:

    1. Yuandi Gao & Laure Guitton-Sert & Julien Dessapt & Yan Coulombe & Amélie Rodrigue & Larissa Milano & Andréanne Blondeau & Nicolai Balle Larsen & Julien P. Duxin & Samer Hussein & Amélie Fradet-Turcott, 2023. "A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Jessica D. Tischler & Hiroshi Tsuchida & Rosevalentine Bosire & Tommy T. Oda & Ana Park & Richard O. Adeyemi, 2024. "FLIP(C1orf112)-FIGNL1 complex regulates RAD51 chromatin association to promote viability after replication stress," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Diana A. Llerena Schiffmacher & Shun-Hsiao Lee & Katarzyna W. Kliza & Arjan F. Theil & Masaki Akita & Angela Helfricht & Karel Bezstarosti & Camila Gonzalo-Hansen & Haico Attikum & Matty Verlaan-de Vr, 2024. "The small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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