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Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae

Author

Listed:
  • Mohan Babu

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Research and Innovation Centre, 3737 Wascana Parkway, University of Regina, Regina, Saskatchewan S4S 0A2, Canada)

  • James Vlasblom

    (Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    1 King’s College Circle, Medical Science Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Shuye Pu

    (Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada)

  • Xinghua Guo

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Chris Graham

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Björn D. M. Bean

    (Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, 950 West 28th Avenue, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada)

  • Helen E. Burston

    (Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, 950 West 28th Avenue, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada)

  • Franco J. Vizeacoumar

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Jamie Snider

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Sadhna Phanse

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Vincent Fong

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Yuen Yi C. Tam

    (Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, 950 West 28th Avenue, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada)

  • Michael Davey

    (Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, 950 West 28th Avenue, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada)

  • Olha Hnatshak

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Navgeet Bajaj

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Shamanta Chandran

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Thanuja Punna

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Constantine Christopolous

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Victoria Wong

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Analyn Yu

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Gouqing Zhong

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Joyce Li

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada)

  • Igor Stagljar

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    1 King’s College Circle, Medical Science Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    1 King’s College Circle, Medical Science Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Elizabeth Conibear

    (Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, 950 West 28th Avenue, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada)

  • Shoshana J. Wodak

    (Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    1 King’s College Circle, Medical Science Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    1 King’s College Circle, Medical Science Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Andrew Emili

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    1 King’s College Circle, Medical Science Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Jack F. Greenblatt

    (Donnelly Centre, 160 College Street, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    1 King’s College Circle, Medical Science Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada)

Abstract

A survey of 1,590 putative integral, peripheral and lipid-anchored membrane proteins from Saccharomyces cerevisiae reveals unexpected physical associations underlying the membrane biology of eukaryotes and delineates the global topological landscape of the membrane interactome.

Suggested Citation

  • Mohan Babu & James Vlasblom & Shuye Pu & Xinghua Guo & Chris Graham & Björn D. M. Bean & Helen E. Burston & Franco J. Vizeacoumar & Jamie Snider & Sadhna Phanse & Vincent Fong & Yuen Yi C. Tam & Micha, 2012. "Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae," Nature, Nature, vol. 489(7417), pages 585-589, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7417:d:10.1038_nature11354
    DOI: 10.1038/nature11354
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    Cited by:

    1. Yannick Weyer & Sinead I. Schwabl & Xuechen Tang & Astha Purwar & Konstantin Siegmann & Angela Ruepp & Theresia Dunzendorfer-Matt & Michael A. Widerin & Veronika Niedrist & Noa J. M. Mutsters & Maria , 2024. "The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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