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A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

Author

Listed:
  • Bethany A. Buckley

    (Laboratory of Genetics, University of Wisconsin-Madison)

  • Kirk B. Burkhart

    (Laboratory of Genetics, University of Wisconsin-Madison)

  • Sam Guoping Gu

    (Stanford University)

  • George Spracklin

    (Laboratory of Genetics, University of Wisconsin-Madison)

  • Aaron Kershner

    (Howard Hughes Medical Institute, University of Wisconsin-Madison)

  • Heidi Fritz

    (Laboratory of Genetics, University of Wisconsin-Madison)

  • Judith Kimble

    (Laboratory of Genetics, University of Wisconsin-Madison
    Howard Hughes Medical Institute, University of Wisconsin-Madison)

  • Andrew Fire

    (Stanford University)

  • Scott Kennedy

    (Laboratory of Genetics, University of Wisconsin-Madison)

Abstract

Double-stranded RNA interference (RNAi) in Caenorhabditis elegans is heritable; here a genetic screen for factors required for RNAi inheritance identifies the nuclear-localized Argonaute gene hrde-1, which acts in the germ cells of progeny to promote multigenerational inheritance of silencing and, also, germline immortality.

Suggested Citation

  • Bethany A. Buckley & Kirk B. Burkhart & Sam Guoping Gu & George Spracklin & Aaron Kershner & Heidi Fritz & Judith Kimble & Andrew Fire & Scott Kennedy, 2012. "A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality," Nature, Nature, vol. 489(7416), pages 447-451, September.
    • Handle: RePEc:nat:nature:v:489:y:2012:i:7416:d:10.1038_nature11352
    DOI: 10.1038/nature11352
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    Cited by:

    1. Noa Deshe & Yifat Eliezer & Lihi Hoch & Eyal Itskovits & Eduard Bokman & Shachaf Ben-Ezra & Alon Zaslaver, 2023. "Inheritance of associative memories and acquired cellular changes in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Shihui Chen & Carolyn M. Phillips, 2024. "HRDE-2 drives small RNA specificity for the nuclear Argonaute protein HRDE-1," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Ian F. Price & Jillian A. Wagner & Benjamin Pastore & Hannah L. Hertz & Wen Tang, 2023. "C. elegans germ granules sculpt both germline and somatic RNAome," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Maxim V. Zagoskin & Jianbin Wang & Ashley T. Neff & Giovana M. B. Veronezi & Richard E. Davis, 2022. "Small RNA pathways in the nematode Ascaris in the absence of piRNAs," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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