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T cells become licensed in the lung to enter the central nervous system

Author

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  • Francesca Odoardi

    (Institute for Multiple Sclerosis Research, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, 37073 Göttingen, Germany)

  • Christopher Sie

    (Institute for Multiple Sclerosis Research, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, 37073 Göttingen, Germany)

  • Kristina Streyl

    (Max Planck Institute for Neurobiology, 82152 Martinsried, Germany)

  • Vijay K. Ulaganathan

    (Max Planck Institute for Neurobiology, 82152 Martinsried, Germany)

  • Christian Schläger

    (Institute for Multiple Sclerosis Research, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, 37073 Göttingen, Germany)

  • Dmitri Lodygin

    (Institute for Multiple Sclerosis Research, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, 37073 Göttingen, Germany)

  • Klaus Heckelsmiller

    (Max Planck Institute for Neurobiology, 82152 Martinsried, Germany)

  • Wilfried Nietfeld

    (Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany)

  • Joachim Ellwart

    (Institute of Molecular Immunology, Helmholtz Zentrum München, 81377 Munich, Germany)

  • Wolfgang E. F. Klinkert

    (Max Planck Institute for Neurobiology, 82152 Martinsried, Germany)

  • Claudio Lottaz

    (Institute for Functional Genomics, University of Regensburg, 93053 Regensburg, Germany)

  • Mikhail Nosov

    (College of Medicine, Nursing and Health Sciences, Regenerative Medicine Institute, National Centre for Biomedical Engineering Science, National University of Ireland, County Galway, Ireland)

  • Volker Brinkmann

    (Autoimmunity, Transplantation and Inflammation Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland)

  • Rainer Spang

    (Institute for Functional Genomics, University of Regensburg, 93053 Regensburg, Germany)

  • Hans Lehrach

    (Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany)

  • Martin Vingron

    (Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany)

  • Hartmut Wekerle

    (Max Planck Institute for Neurobiology, 82152 Martinsried, Germany)

  • Cassandra Flügel-Koch

    (Institute for Anatomy II, Friedrich Alexander University, 91054 Erlangen, Germany)

  • Alexander Flügel

    (Institute for Multiple Sclerosis Research, Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, 37073 Göttingen, Germany)

Abstract

A Lewis rat model of experimental autoimmune encephalomyelitis is used to show that on their way to the CNS, encephalitogenic T-cell blasts are temporarily resident in the lung, where they reprogram their gene-expression profile and functional properties to enable them to transgress the blood–brain barrier into the CNS.

Suggested Citation

  • Francesca Odoardi & Christopher Sie & Kristina Streyl & Vijay K. Ulaganathan & Christian Schläger & Dmitri Lodygin & Klaus Heckelsmiller & Wilfried Nietfeld & Joachim Ellwart & Wolfgang E. F. Klinkert, 2012. "T cells become licensed in the lung to enter the central nervous system," Nature, Nature, vol. 488(7413), pages 675-679, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7413:d:10.1038_nature11337
    DOI: 10.1038/nature11337
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    Cited by:

    1. Swee Heng Milon Pang & Joshua D’Rozario & Senora Mendonca & Tejasvini Bhuvan & Natalie L. Payne & Di Zheng & Assifa Hisana & Georgia Wallis & Adele Barugahare & David Powell & Jai Rautela & Nicholas D, 2021. "Mesenchymal stromal cell apoptosis is required for their therapeutic function," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    2. Vitaly V Ganusov & Jeremy Auerbach, 2014. "Mathematical Modeling Reveals Kinetics of Lymphocyte Recirculation in the Whole Organism," PLOS Computational Biology, Public Library of Science, vol. 10(5), pages 1-15, May.
    3. Davide Frumento, 2020. "Blood-Brain Barrier Disruption as a Key Role Problem in Multiple Sclerosis - A Novel Primary Prevention Strategy," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 24(2), pages 18038-18041, January.

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