IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v488y2012i7412d10.1038_nature11269.html
   My bibliography  Save this article

The human CST complex is a terminator of telomerase activity

Author

Listed:
  • Liuh-Yow Chen

    (Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Frontiers in Genetics National Center of Competence in Research, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 19, 1015 Lausanne, Switzerland)

  • Sophie Redon

    (Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Frontiers in Genetics National Center of Competence in Research, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 19, 1015 Lausanne, Switzerland)

  • Joachim Lingner

    (Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Frontiers in Genetics National Center of Competence in Research, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 19, 1015 Lausanne, Switzerland)

Abstract

The human CST complex is shown to interact with the telomeric primer and the POT1–TPP1 complex to inhibit telomerase activity in late S phase, thereby keeping unrestrained telomere lengthening in check.

Suggested Citation

  • Liuh-Yow Chen & Sophie Redon & Joachim Lingner, 2012. "The human CST complex is a terminator of telomerase activity," Nature, Nature, vol. 488(7412), pages 540-544, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7412:d:10.1038_nature11269
    DOI: 10.1038/nature11269
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11269
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11269?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kai-Hang Lei & Han-Lin Yang & Hao-Yen Chang & Hsin-Yi Yeh & Dinh Duc Nguyen & Tzu-Yu Lee & Xinxing Lyu & Megan Chastain & Weihang Chai & Hung-Wen Li & Peter Chi, 2021. "Crosstalk between CST and RPA regulates RAD51 activity during replication stress," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Rishi Kumar Jaiswal & Kai-Hang Lei & Megan Chastain & Yuan Wang & Olga Shiva & Shan Li & Zhongsheng You & Peter Chi & Weihang Chai, 2023. "CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:488:y:2012:i:7412:d:10.1038_nature11269. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.