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Activation of specific interneurons improves V1 feature selectivity and visual perception

Author

Listed:
  • Seung-Hee Lee

    (Helen Wills Neuroscience Institute, University of California
    Howard Hughes Medical Institute, University of California)

  • Alex C. Kwan

    (Helen Wills Neuroscience Institute, University of California)

  • Siyu Zhang

    (Helen Wills Neuroscience Institute, University of California)

  • Victoria Phoumthipphavong

    (Helen Wills Neuroscience Institute, University of California)

  • John G. Flannery

    (Helen Wills Neuroscience Institute, University of California)

  • Sotiris C. Masmanidis

    (Broad Fellows Program in Brain Circuitry, Kavli Nanoscience Institute, California Institute of Technology)

  • Hiroki Taniguchi

    (Cold Spring Harbor Laboratory)

  • Z. Josh Huang

    (Cold Spring Harbor Laboratory)

  • Feng Zhang

    (Howard Hughes Medical Institute, Stanford University)

  • Edward S. Boyden

    (Media Laboratory, Biological Engineering, Brain and Cognitive Sciences, and McGovern Institute, Massachusetts Institute of Technology)

  • Karl Deisseroth

    (Howard Hughes Medical Institute, Stanford University)

  • Yang Dan

    (Helen Wills Neuroscience Institute, University of California
    Howard Hughes Medical Institute, University of California)

Abstract

Optogenetic activation of parvalbumin-expressing versus other classes of interneurons is found to have distinct effects on the response properties of individual and populations of excitatory cells, as well as on visual behaviour in awake mice, providing evidence that this specific interneuron subtype has a unique role in visual coding and perception.

Suggested Citation

  • Seung-Hee Lee & Alex C. Kwan & Siyu Zhang & Victoria Phoumthipphavong & John G. Flannery & Sotiris C. Masmanidis & Hiroki Taniguchi & Z. Josh Huang & Feng Zhang & Edward S. Boyden & Karl Deisseroth & , 2012. "Activation of specific interneurons improves V1 feature selectivity and visual perception," Nature, Nature, vol. 488(7411), pages 379-383, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7411:d:10.1038_nature11312
    DOI: 10.1038/nature11312
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    Cited by:

    1. Masakazu Agetsuma & Issei Sato & Yasuhiro R. Tanaka & Luis Carrillo-Reid & Atsushi Kasai & Atsushi Noritake & Yoshiyuki Arai & Miki Yoshitomo & Takashi Inagaki & Hiroshi Yukawa & Hitoshi Hashimoto & J, 2023. "Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Alexandre Castonguay & Sébastien Thomas & Frédéric Lesage & Christian Casanova, 2014. "Repetitive and Retinotopically Restricted Activation of the Dorsal Lateral Geniculate Nucleus with Optogenetics," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-8, April.
    3. Ke Chen & Ai-Min Ding & Xiao-Hua Liang & Li-Peng Zhang & Ling Wang & Xue-Mei Song, 2015. "Effect of Contrast on Visual Spatial Summation in Different Cell Categories in Cat Primary Visual Cortex," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-14, December.

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