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Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

Author

Listed:
  • Orit Rozenblatt-Rosen

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Rahul C. Deo

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Harvard Medical School
    Cardiovascular Research Institute, University of California)

  • Megha Padi

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Center for Cancer Computational Biology (CCCB), Dana-Farber Cancer Institute
    Harvard School of Public Health)

  • Guillaume Adelmant

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Harvard Medical School
    Dana-Farber Cancer Institute)

  • Michael A. Calderwood

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School
    The Channing Laboratory, Harvard Medical School)

  • Thomas Rolland

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Miranda Grace

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Harvard Medical School)

  • Amélie Dricot

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Manor Askenazi

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Harvard Medical School
    Dana-Farber Cancer Institute)

  • Maria Tavares

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School
    Dana-Farber Cancer Institute)

  • Samuel J. Pevzner

    (Dana-Farber Cancer Institute
    Harvard Medical School
    Boston University and Boston University School of Medicine)

  • Fieda Abderazzaq

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Center for Cancer Computational Biology (CCCB), Dana-Farber Cancer Institute)

  • Danielle Byrdsong

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Anne-Ruxandra Carvunis

    (Dana-Farber Cancer Institute
    Harvard Medical School)

  • Alyce A. Chen

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Harvard Medical School)

  • Jingwei Cheng

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Mick Correll

    (Center for Cancer Computational Biology (CCCB), Dana-Farber Cancer Institute)

  • Melissa Duarte

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    The Channing Laboratory, Harvard Medical School)

  • Changyu Fan

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Mariet C. Feltkamp

    (Leiden University Medical Center, 2300 RC Leiden, The Netherlands)

  • Scott B. Ficarro

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Harvard Medical School
    Dana-Farber Cancer Institute)

  • Rachel Franchi

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Simmons College)

  • Brijesh K. Garg

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Harvard Medical School
    Dana-Farber Cancer Institute)

  • Natali Gulbahce

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Northeastern University
    University of California)

  • Tong Hao

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Amy M. Holthaus

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    The Channing Laboratory, Harvard Medical School)

  • Robert James

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Anna Korkhin

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Larisa Litovchick

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Jessica C. Mar

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Center for Cancer Computational Biology (CCCB), Dana-Farber Cancer Institute
    Harvard School of Public Health)

  • Theodore R. Pak

    (University of Toronto and Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario M5G 1X5, Canada)

  • Sabrina Rabello

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School
    Dana-Farber Cancer Institute
    Northeastern University)

  • Renee Rubio

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Center for Cancer Computational Biology (CCCB), Dana-Farber Cancer Institute)

  • Yun Shen

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Saurav Singh

    (Harvard Medical School
    Dana-Farber Cancer Institute)

  • Jennifer M. Spangle

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Harvard Medical School)

  • Murat Tasan

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Harvard Medical School
    University of Toronto and Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario M5G 1X5, Canada)

  • Shelly Wanamaker

    (Dana-Farber Cancer Institute
    Harvard Medical School
    Simmons College)

  • James T. Webber

    (Harvard Medical School
    Dana-Farber Cancer Institute)

  • Jennifer Roecklein-Canfield

    (Dana-Farber Cancer Institute
    Simmons College)

  • Eric Johannsen

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    The Channing Laboratory, Harvard Medical School)

  • Albert-László Barabási

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School
    Dana-Farber Cancer Institute
    Northeastern University)

  • Rameen Beroukhim

    (Brigham and Women’s Hospital, Harvard Medical School
    Dana-Farber Cancer Institute
    The Broad Institute)

  • Elliott Kieff

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    The Channing Laboratory, Harvard Medical School)

  • Michael E. Cusick

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • David E. Hill

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

  • Karl Münger

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Harvard Medical School)

  • Jarrod A. Marto

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Harvard Medical School
    Dana-Farber Cancer Institute)

  • John Quackenbush

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Center for Cancer Computational Biology (CCCB), Dana-Farber Cancer Institute
    Harvard School of Public Health)

  • Frederick P. Roth

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Harvard Medical School
    Dana-Farber Cancer Institute
    University of Toronto and Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario M5G 1X5, Canada)

  • James A. DeCaprio

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Brigham and Women’s Hospital, Harvard Medical School)

  • Marc Vidal

    (Genomic Analysis of Network Perturbations Center of Excellence in Genomic Science, Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute
    Dana-Farber Cancer Institute
    Harvard Medical School)

Abstract

Combining analysis of host proteome and transcriptome perturbations induced by tumour virus proteins with ongoing genome-wide studies of cancer facilitates the prioritization of cancer genes.

Suggested Citation

  • Orit Rozenblatt-Rosen & Rahul C. Deo & Megha Padi & Guillaume Adelmant & Michael A. Calderwood & Thomas Rolland & Miranda Grace & Amélie Dricot & Manor Askenazi & Maria Tavares & Samuel J. Pevzner & F, 2012. "Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins," Nature, Nature, vol. 487(7408), pages 491-495, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7408:d:10.1038_nature11288
    DOI: 10.1038/nature11288
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    Cited by:

    1. Nilesh Kumar & M. Shahid Mukhtar, 2024. "Viral Targets in the Human Interactome with Comprehensive Centrality Analysis: SARS-CoV-2, a Case Study," Data, MDPI, vol. 9(8), pages 1-12, August.
    2. Hong-Wen Tang & Kerstin Spirohn & Yanhui Hu & Tong Hao & István A. Kovács & Yue Gao & Richard Binari & Donghui Yang-Zhou & Kenneth H. Wan & Joel S. Bader & Dawit Balcha & Wenting Bian & Benjamin W. Bo, 2023. "Next-generation large-scale binary protein interaction network for Drosophila melanogaster," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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