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Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

Author

Listed:
  • Timothy R. Wilson

    (Research Oncology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Jane Fridlyand

    (Biostatastics, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Yibing Yan

    (Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Elicia Penuel

    (Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Luciana Burton

    (Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Emily Chan

    (Research Oncology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Jing Peng

    (Research Oncology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Eva Lin

    (Research Oncology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Yulei Wang

    (Development Sciences, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Jeff Sosman

    (Vanderbilt University Medical Center, 777 Preston Research Building, Nashville, Tennessee 37232, USA)

  • Antoni Ribas

    (Jonsson Comprehensive Cancer Center, University of California Los Angeles, 9-954 Factor Building, 10833 Le Conte Avenue, Los Angeles, California 90095, USA)

  • Jiang Li

    (Medical Developmental Biometrics Biostatistics, Roche Nutley, 340 Kingsland Street, Nutley, New Jersey 07110, USA)

  • John Moffat

    (Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Daniel P. Sutherlin

    (Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Hartmut Koeppen

    (Research Pathology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Mark Merchant

    (Research Oncology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Richard Neve

    (Research Oncology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Jeff Settleman

    (Research Oncology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

Abstract

The efficacy of kinase inhibitors in treating cancer is limited by drug resistance; here it is shown that most human tumour cells can develop drug resistance through being exposed to one or more receptor tyrosine kinase ligands.

Suggested Citation

  • Timothy R. Wilson & Jane Fridlyand & Yibing Yan & Elicia Penuel & Luciana Burton & Emily Chan & Jing Peng & Eva Lin & Yulei Wang & Jeff Sosman & Antoni Ribas & Jiang Li & John Moffat & Daniel P. Suthe, 2012. "Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors," Nature, Nature, vol. 487(7408), pages 505-509, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7408:d:10.1038_nature11249
    DOI: 10.1038/nature11249
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    Cited by:

    1. Jiaxin Liang & Deyang Yu & Chi Luo & Christopher Bennett & Mark Jedrychowski & Steve P. Gygi & Hans R. Widlund & Pere Puigserver, 2023. "Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Ke Gong & Gao Guo & Nicole A. Beckley & Xiaoyao Yang & Yue Zhang & David E. Gerber & John D. Minna & Sandeep Burma & Dawen Zhao & Esra A. Akbay & Amyn A. Habib, 2021. "Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    3. Daniel E Carlin & Barry Demchak & Dexter Pratt & Eric Sage & Trey Ideker, 2017. "Network propagation in the cytoscape cyberinfrastructure," PLOS Computational Biology, Public Library of Science, vol. 13(10), pages 1-9, October.
    4. David Gonzalez-Martinez & Lee Roth & Thomas R. Mumford & Juan Guan & Anh Le & Robert C. Doebele & Bo Huang & Asmin Tulpule & Magdalena Niewiadomska-Bugaj & Trever G. Bivona & Lukasz J. Bugaj, 2024. "Oncogenic EML4-ALK assemblies suppress growth factor perception and modulate drug tolerance," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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