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An epigenetic silencing pathway controlling T helper 2 cell lineage commitment

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  • Rhys S. Allan

    (Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    INSERM U932, Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    Present addresses: Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia (R.S.A.); Laboratory of Molecular Immunology and Rockefeller University, 1230 York Avenue, New York, New York 10065, USA (H.A.S.); Laboratory of Proteomic Mass Spectrometry, Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France (V.M.).)

  • Elina Zueva

    (Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    INSERM U932, Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • Florence Cammas

    (Institut de Recherche en Cancérologie de Montpellier, CRLC Val d’Aurelle-Paul Lamarque, 34298 Montpellier Cedex 5, France)

  • Heidi A. Schreiber

    (Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    INSERM U932, Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    Present addresses: Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia (R.S.A.); Laboratory of Molecular Immunology and Rockefeller University, 1230 York Avenue, New York, New York 10065, USA (H.A.S.); Laboratory of Proteomic Mass Spectrometry, Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France (V.M.).)

  • Vanessa Masson

    (Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    INSERM U932, Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    Present addresses: Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia (R.S.A.); Laboratory of Molecular Immunology and Rockefeller University, 1230 York Avenue, New York, New York 10065, USA (H.A.S.); Laboratory of Proteomic Mass Spectrometry, Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France (V.M.).)

  • Gabrielle T. Belz

    (Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)

  • Danièle Roche

    (Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    CNRS UMR218, Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • Christèle Maison

    (Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    CNRS UMR218, Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • Jean-Pierre Quivy

    (Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    CNRS UMR218, Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • Geneviève Almouzni

    (Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    CNRS UMR218, Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

  • Sebastian Amigorena

    (Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France
    INSERM U932, Institut Curie Research Center, 26 rue d’Ulm, 75248 Paris Cedex 05, France)

Abstract

The histone modification H3K9me3, the histone methyltransferase SUV39H1 and the H3K9me3-binding protein HP1α participate in maintaining the silent state of the two canonical T helper 1 cell signature genes (which encode interferon-γ and T-bet), ensuring T helper 2 lineage stability in vitro and in vivo; targeting this pathway has the potential to reduce asthma-related pathology.

Suggested Citation

  • Rhys S. Allan & Elina Zueva & Florence Cammas & Heidi A. Schreiber & Vanessa Masson & Gabrielle T. Belz & Danièle Roche & Christèle Maison & Jean-Pierre Quivy & Geneviève Almouzni & Sebastian Amigoren, 2012. "An epigenetic silencing pathway controlling T helper 2 cell lineage commitment," Nature, Nature, vol. 487(7406), pages 249-253, July.
    • Handle: RePEc:nat:nature:v:487:y:2012:i:7406:d:10.1038_nature11173
    DOI: 10.1038/nature11173
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    Cited by:

    1. Leticia Laura Niborski & Paul Gueguen & Mengliang Ye & Allan Thiolat & Rodrigo Nalio Ramos & Pamela Caudana & Jordan Denizeau & Ludovic Colombeau & Raphaël Rodriguez & Christel Goudot & Jean-Michel Lu, 2022. "CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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