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Programmable single-cell mammalian biocomputers

Author

Listed:
  • Simon Ausländer

    (Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland)

  • David Ausländer

    (Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland)

  • Marius Müller

    (Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland)

  • Markus Wieland

    (Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland)

  • Martin Fussenegger

    (Eidgenössische Technische Hochschule Zürich, Mattenstrasse 26, CH-4058 Basel, Switzerland
    Faculty of Science, University of Basel, Mattenstrasse 26, CH-4058 Basel, Switzerland)

Abstract

In synthetic biology, the use of regulatory proteins that bind either DNA or RNA to reprogram mammalian cellular functions allows a variety of computational ‘logic circuits’ to be built in a plug-and-play manner, which may pave the way for precise and robust control of future gene-based and cell-based therapies.

Suggested Citation

  • Simon Ausländer & David Ausländer & Marius Müller & Markus Wieland & Martin Fussenegger, 2012. "Programmable single-cell mammalian biocomputers," Nature, Nature, vol. 487(7405), pages 123-127, July.
  • Handle: RePEc:nat:nature:v:487:y:2012:i:7405:d:10.1038_nature11149
    DOI: 10.1038/nature11149
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    Cited by:

    1. Shunsuke Kawasaki & Hiroki Ono & Moe Hirosawa & Takeru Kuwabara & Shunsuke Sumi & Suji Lee & Knut Woltjen & Hirohide Saito, 2023. "Programmable mammalian translational modulators by CRISPR-associated proteins," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Yafeng Wang & Guiquan Zhang & Qingzhou Meng & Shisheng Huang & Panpan Guo & Qibin Leng & Lingyun Sun & Geng Liu & Xingxu Huang & Jianghuai Liu, 2022. "Precise tumor immune rewiring via synthetic CRISPRa circuits gated by concurrent gain/loss of transcription factors," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Linlin Tang & Zhijin Tian & Jin Cheng & Yijing Zhang & Yongxiu Song & Yan Liu & Jinghao Wang & Pengfei Zhang & Yonggang Ke & Friedrich C. Simmel & Jie Song, 2023. "Circular single-stranded DNA as switchable vector for gene expression in mammalian cells," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Breanna DiAndreth & Noreen Wauford & Eileen Hu & Sebastian Palacios & Ron Weiss, 2022. "PERSIST platform provides programmable RNA regulation using CRISPR endoRNases," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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