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Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

Author

Listed:
  • Sandra Misale

    (Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy
    University of Torino Medical School, 10060 Candiolo (Torino), Italy)

  • Rona Yaeger

    (Memorial Sloan-Kettering Cancer Center)

  • Sebastijan Hobor

    (Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy)

  • Elisa Scala

    (Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy
    University of Torino Medical School, 10060 Candiolo (Torino), Italy)

  • Manickam Janakiraman

    (Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • David Liska

    (Memorial Sloan-Kettering Cancer Center)

  • Emanuele Valtorta

    (Ospedale Niguarda Ca’ Granda, 20162 Milano, Italy)

  • Roberta Schiavo

    (Ospedale Niguarda Ca’ Granda, 20162 Milano, Italy)

  • Michela Buscarino

    (Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy
    University of Torino Medical School, 10060 Candiolo (Torino), Italy)

  • Giulia Siravegna

    (Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy)

  • Katia Bencardino

    (Ospedale Niguarda Ca’ Granda, 20162 Milano, Italy)

  • Andrea Cercek

    (Memorial Sloan-Kettering Cancer Center)

  • Chin-Tung Chen

    (Memorial Sloan-Kettering Cancer Center)

  • Silvio Veronese

    (Ospedale Niguarda Ca’ Granda, 20162 Milano, Italy)

  • Carlo Zanon

    (Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy)

  • Andrea Sartore-Bianchi

    (Ospedale Niguarda Ca’ Granda, 20162 Milano, Italy)

  • Marcello Gambacorta

    (Ospedale Niguarda Ca’ Granda, 20162 Milano, Italy)

  • Margherita Gallicchio

    (University of Torino, 10125 Torino, Italy)

  • Efsevia Vakiani

    (Memorial Sloan-Kettering Cancer Center)

  • Valentina Boscaro

    (University of Torino, 10125 Torino, Italy)

  • Enzo Medico

    (University of Torino Medical School, 10060 Candiolo (Torino), Italy
    Laboratory of Functional Genomics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy)

  • Martin Weiser

    (Memorial Sloan-Kettering Cancer Center)

  • Salvatore Siena

    (Ospedale Niguarda Ca’ Granda, 20162 Milano, Italy)

  • Federica Di Nicolantonio

    (Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy
    FIRC Institute of Molecular Oncology (IFOM), 20139 Milano, Italy)

  • David Solit

    (Memorial Sloan-Kettering Cancer Center
    Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center)

  • Alberto Bardelli

    (Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy
    University of Torino Medical School, 10060 Candiolo (Torino), Italy
    FIRC Institute of Molecular Oncology (IFOM), 20139 Milano, Italy)

Abstract

Molecular alterations in KRAS are associated with acquired resistance to anti-epidermal growth factor receptor (EGFR) treatment in colorectal cancer; resistant mutations can be identified in the blood of patients, months before clinical evidence of disease progression.

Suggested Citation

  • Sandra Misale & Rona Yaeger & Sebastijan Hobor & Elisa Scala & Manickam Janakiraman & David Liska & Emanuele Valtorta & Roberta Schiavo & Michela Buscarino & Giulia Siravegna & Katia Bencardino & Andr, 2012. "Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer," Nature, Nature, vol. 486(7404), pages 532-536, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7404:d:10.1038_nature11156
    DOI: 10.1038/nature11156
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    Cited by:

    1. Dustin J. Flanagan & Raheleh Amirkhah & David F. Vincent & Nuray Gunduz & Pauline Gentaz & Patrizia Cammareri & Aoife J. McCooey & Amy M. B. McCorry & Natalie C. Fisher & Hayley L. Davis & Rachel A. R, 2022. "Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Radia M. Johnson & Xueping Qu & Chu-Fang Lin & Ling-Yuh Huw & Avinashnarayan Venkatanarayan & Ethan Sokol & Fang-Shu Ou & Nnamdi Ihuegbu & Oliver A. Zill & Omar Kabbarah & Lisa Wang & Richard Bourgon , 2022. "ARID1A mutations confer intrinsic and acquired resistance to cetuximab treatment in colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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