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NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants

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  • Zheng Qing Fu

    (Howard Hughes Medical Institute–Gordon and Betty Moore Foundation, PO Box 90338, Duke University)

  • Shunping Yan

    (Howard Hughes Medical Institute–Gordon and Betty Moore Foundation, PO Box 90338, Duke University)

  • Abdelaty Saleh

    (Howard Hughes Medical Institute–Gordon and Betty Moore Foundation, PO Box 90338, Duke University)

  • Wei Wang

    (Howard Hughes Medical Institute–Gordon and Betty Moore Foundation, PO Box 90338, Duke University)

  • James Ruble

    (Howard Hughes Medical Institute, University of Washington, PO Box 357280, Seattle, Washington 98195, USA)

  • Nodoka Oka

    (Faculty of Agriculture, Kagawa University, Miki, Kagawa 761-0795, Japan)

  • Rajinikanth Mohan

    (Howard Hughes Medical Institute–Gordon and Betty Moore Foundation, PO Box 90338, Duke University)

  • Steven H. Spoel

    (Institute of Molecular Plant Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK)

  • Yasuomi Tada

    (Life Science Research Center, Institute of Research Promotion, Kagawa University, 2393 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0795, Japan)

  • Ning Zheng

    (Howard Hughes Medical Institute, University of Washington, PO Box 357280, Seattle, Washington 98195, USA)

  • Xinnian Dong

    (Howard Hughes Medical Institute–Gordon and Betty Moore Foundation, PO Box 90338, Duke University)

Abstract

Salicylic acid (SA) is a plant immune signal produced after pathogen challenge to induce systemic acquired resistance. It is the only major plant hormone for which the receptor has not been firmly identified. Systemic acquired resistance in Arabidopsis requires the transcription cofactor nonexpresser of PR genes 1 (NPR1), the degradation of which acts as a molecular switch. Here we show that the NPR1 paralogues NPR3 and NPR4 are SA receptors that bind SA with different affinities. NPR3 and NPR4 function as adaptors of the Cullin 3 ubiquitin E3 ligase to mediate NPR1 degradation in an SA-regulated manner. Accordingly, the Arabidopsis npr3 npr4 double mutant accumulates higher levels of NPR1, and is insensitive to induction of systemic acquired resistance. Moreover, this mutant is defective in pathogen effector-triggered programmed cell death and immunity. Our study reveals the mechanism of SA perception in determining cell death and survival in response to pathogen challenge.

Suggested Citation

  • Zheng Qing Fu & Shunping Yan & Abdelaty Saleh & Wei Wang & James Ruble & Nodoka Oka & Rajinikanth Mohan & Steven H. Spoel & Yasuomi Tada & Ning Zheng & Xinnian Dong, 2012. "NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants," Nature, Nature, vol. 486(7402), pages 228-232, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7402:d:10.1038_nature11162
    DOI: 10.1038/nature11162
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    Cited by:

    1. Wen Li & Peng Li & Yizhen Deng & Junjian Situ & Zhuoyuan He & Wenzhe Zhou & Minhui Li & Pinggen Xi & Xiangxiu Liang & Guanghui Kong & Zide Jiang, 2024. "A plant cell death-inducing protein from litchi interacts with Peronophythora litchii pectate lyase and enhances plant resistance," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Hehong Zhang & Fengmin Wang & Weiqi Song & Zihang Yang & Lulu Li & Qiang Ma & Xiaoxiang Tan & Zhongyan Wei & Yanjun Li & Junmin Li & Fei Yan & Jianping Chen & Zongtao Sun, 2023. "Different viral effectors suppress hormone-mediated antiviral immunity of rice coordinated by OsNPR1," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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