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An oxygen-regulated switch in the protein synthesis machinery

Author

Listed:
  • James Uniacke

    (Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5)

  • Chet E. Holterman

    (Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5)

  • Gabriel Lachance

    (Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5)

  • Aleksandra Franovic

    (Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5)

  • Mathieu D. Jacob

    (Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5)

  • Marc R. Fabian

    (Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada H3G 1Y6)

  • Josianne Payette

    (Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5)

  • Martin Holcik

    (Apoptosis Research Centre, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada K1H 8L1)

  • Arnim Pause

    (Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada H3G 1Y6)

  • Stephen Lee

    (Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5)

Abstract

Hypoxia activates a translation initiation pathway that escapes global inhibition of protein synthesis.

Suggested Citation

  • James Uniacke & Chet E. Holterman & Gabriel Lachance & Aleksandra Franovic & Mathieu D. Jacob & Marc R. Fabian & Josianne Payette & Martin Holcik & Arnim Pause & Stephen Lee, 2012. "An oxygen-regulated switch in the protein synthesis machinery," Nature, Nature, vol. 486(7401), pages 126-129, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7401:d:10.1038_nature11055
    DOI: 10.1038/nature11055
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    Cited by:

    1. Mykola Roiuk & Marilena Neff & Aurelio A. Teleman, 2024. "eIF4E-independent translation is largely eIF3d-dependent," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Bella M. Ben-Oz & Feras E. Machour & Marian Nicola & Amir Argoetti & Galia Polyak & Rawad Hanna & Oded Kleifeld & Yael Mandel-Gutfreund & Nabieh Ayoub, 2023. "A dual role of RBM42 in modulating splicing and translation of CDKN1A/p21 during DNA damage response," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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