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Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

Author

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  • Xu Zhang

    (State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
    Tsinghua-Peking Center for Life Sciences, Tsinghua University)

  • Wenlin Ren

    (State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
    Tsinghua-Peking Center for Life Sciences, Tsinghua University)

  • Paul DeCaen

    (Howard Hughes Medical Institute, Children’s Hospital Boston
    Harvard Medical School)

  • Chuangye Yan

    (State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
    Tsinghua-Peking Center for Life Sciences, Tsinghua University)

  • Xiao Tao

    (Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA)

  • Lin Tang

    (Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 239 Zhangheng Road, Shanghai 201204, China)

  • Jingjing Wang

    (State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China)

  • Kazuya Hasegawa

    (Japan Synchrotron Radiation Research Institute (SPring-8), 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan)

  • Takashi Kumasaka

    (Japan Synchrotron Radiation Research Institute (SPring-8), 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan)

  • Jianhua He

    (Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 239 Zhangheng Road, Shanghai 201204, China)

  • Jiawei Wang

    (State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University)

  • David E. Clapham

    (Howard Hughes Medical Institute, Children’s Hospital Boston
    Harvard Medical School)

  • Nieng Yan

    (State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
    Tsinghua-Peking Center for Life Sciences, Tsinghua University)

Abstract

The crystal structure of NavRh, a NaChBac orthologue from the marine Rickettsiales sp. HIMB114, defines an ion binding site within the selectivity filter, and reveals several conformational rearrangements that may underlie the electromechanical coupling mechanism.

Suggested Citation

  • Xu Zhang & Wenlin Ren & Paul DeCaen & Chuangye Yan & Xiao Tao & Lin Tang & Jingjing Wang & Kazuya Hasegawa & Takashi Kumasaka & Jianhua He & Jiawei Wang & David E. Clapham & Nieng Yan, 2012. "Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel," Nature, Nature, vol. 486(7401), pages 130-134, June.
    • Handle: RePEc:nat:nature:v:486:y:2012:i:7401:d:10.1038_nature11054
    DOI: 10.1038/nature11054
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    Citations

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    Cited by:

    1. Jian Huang & Xiao Fan & Xueqin Jin & Sooyeon Jo & Hanxiong Bear Zhang & Akie Fujita & Bruce P. Bean & Nieng Yan, 2023. "Cannabidiol inhibits Nav channels through two distinct binding sites," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    2. Huiwen Chen & Zhanyi Xia & Jie Dong & Bo Huang & Jiangtao Zhang & Feng Zhou & Rui Yan & Yiqiang Shi & Jianke Gong & Juquan Jiang & Zhuo Huang & Daohua Jiang, 2024. "Structural mechanism of voltage-gated sodium channel slow inactivation," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    3. Qiurong Wu & Jian Huang & Xiao Fan & Kan Wang & Xueqin Jin & Gaoxingyu Huang & Jiaao Li & Xiaojing Pan & Nieng Yan, 2023. "Structural mapping of Nav1.7 antagonists," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    4. Cheng Zhao & Yuan Xie & Lizhen Xu & Fan Ye & Ximing Xu & Wei Yang & Fan Yang & Jiangtao Guo, 2022. "Structures of a mammalian TRPM8 in closed state," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    5. Xingya Li & Gengping Jiang & Meipeng Jian & Chen Zhao & Jue Hou & Aaron W. Thornton & Xinyi Zhang & Jefferson Zhe Liu & Benny D. Freeman & Huanting Wang & Lei Jiang & Huacheng Zhang, 2023. "Construction of angstrom-scale ion channels with versatile pore configurations and sizes by metal-organic frameworks," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    6. Lige Tonggu & Goragot Wisedchaisri & Tamer M. Gamal El-Din & Michael J. Lenaeus & Matthew M. Logan & Tatsuya Toma & Justin Bois & Ning Zheng & William A. Catterall, 2024. "Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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