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Peroxiredoxins are conserved markers of circadian rhythms

Author

Listed:
  • Rachel S. Edgar

    (University of Cambridge Metabolic Research Laboratories, NIHR Biomedical Research Centre, Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK)

  • Edward W. Green

    (University of Leicester, Leicester LE1 7RH, UK)

  • Yuwei Zhao

    (Vanderbilt University)

  • Gerben van Ooijen

    (Synthetic and Systems Biology (SynthSys), Mayfield Road, Edinburgh EH9 3JD, UK)

  • Maria Olmedo

    (Center for Life Sciences, University of Groningen, 9700 CC Groningen, The Netherlands)

  • Ximing Qin

    (Vanderbilt University)

  • Yao Xu

    (Vanderbilt University)

  • Min Pan

    (Institute for Systems Biology, 401 Terry Avenue North)

  • Utham K. Valekunja

    (University of Cambridge Metabolic Research Laboratories, NIHR Biomedical Research Centre, Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK)

  • Kevin A. Feeney

    (University of Cambridge Metabolic Research Laboratories, NIHR Biomedical Research Centre, Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK)

  • Elizabeth S. Maywood

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK)

  • Michael H. Hastings

    (MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK)

  • Nitin S. Baliga

    (Institute for Systems Biology, 401 Terry Avenue North)

  • Martha Merrow

    (Center for Life Sciences, University of Groningen, 9700 CC Groningen, The Netherlands)

  • Andrew J. Millar

    (Synthetic and Systems Biology (SynthSys), Mayfield Road, Edinburgh EH9 3JD, UK
    School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK)

  • Carl H. Johnson

    (Vanderbilt University)

  • Charalambos P. Kyriacou

    (University of Leicester, Leicester LE1 7RH, UK)

  • John S. O’Neill

    (University of Cambridge Metabolic Research Laboratories, NIHR Biomedical Research Centre, Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK)

  • Akhilesh B. Reddy

    (University of Cambridge Metabolic Research Laboratories, NIHR Biomedical Research Centre, Institute of Metabolic Science, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK)

Abstract

Cellular life emerged ∼3.7 billion years ago. With scant exception, terrestrial organisms have evolved under predictable daily cycles owing to the Earth’s rotation. The advantage conferred on organisms that anticipate such environmental cycles has driven the evolution of endogenous circadian rhythms that tune internal physiology to external conditions. The molecular phylogeny of mechanisms driving these rhythms has been difficult to dissect because identified clock genes and proteins are not conserved across the domains of life: Bacteria, Archaea and Eukaryota. Here we show that oxidation–reduction cycles of peroxiredoxin proteins constitute a universal marker for circadian rhythms in all domains of life, by characterizing their oscillations in a variety of model organisms. Furthermore, we explore the interconnectivity between these metabolic cycles and transcription–translation feedback loops of the clockwork in each system. Our results suggest an intimate co-evolution of cellular timekeeping with redox homeostatic mechanisms after the Great Oxidation Event ∼2.5 billion years ago.

Suggested Citation

  • Rachel S. Edgar & Edward W. Green & Yuwei Zhao & Gerben van Ooijen & Maria Olmedo & Ximing Qin & Yao Xu & Min Pan & Utham K. Valekunja & Kevin A. Feeney & Elizabeth S. Maywood & Michael H. Hastings & , 2012. "Peroxiredoxins are conserved markers of circadian rhythms," Nature, Nature, vol. 485(7399), pages 459-464, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7399:d:10.1038_nature11088
    DOI: 10.1038/nature11088
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    Cited by:

    1. Miha Moškon & Tadeja Režen & Matevž Juvančič & Špela Verovšek, 2022. "Integrative Analysis of Rhythmicity: From Biology to Urban Environments and Sustainability," IJERPH, MDPI, vol. 20(1), pages 1-13, December.
    2. Yuqing He & Yingjun Yu & Xiling Wang & Yumei Qin & Chen Su & Lei Wang, 2022. "Aschoff’s rule on circadian rhythms orchestrated by blue light sensor CRY2 and clock component PRR9," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Maxim E. Astashev & Dmitriy A. Serov & Sergey V. Gudkov, 2023. "Application of Spectral Methods of Analysis for Description of Ultradian Biorhythms at the Levels of Physiological Systems, Cells and Molecules (Review)," Mathematics, MDPI, vol. 11(15), pages 1-51, July.

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