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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

Author

Listed:
  • Takafumi Oka

    (Osaka University Graduate School of Medicine)

  • Shungo Hikoso

    (Osaka University Graduate School of Medicine)

  • Osamu Yamaguchi

    (Osaka University Graduate School of Medicine)

  • Manabu Taneike

    (Osaka University Graduate School of Medicine
    King’s College London, London SE5 9NU, UK)

  • Toshihiro Takeda

    (Osaka University Graduate School of Medicine)

  • Takahito Tamai

    (Osaka University Graduate School of Medicine)

  • Jota Oyabu

    (Osaka University Graduate School of Medicine)

  • Tomokazu Murakawa

    (Osaka University Graduate School of Medicine)

  • Hiroyuki Nakayama

    (Graduate School of Pharmaceutical Sciences, Osaka University)

  • Kazuhiko Nishida

    (Osaka University Graduate School of Medicine
    King’s College London, London SE5 9NU, UK)

  • Shizuo Akira

    (Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University
    Research Institute for Microbial Diseases, Osaka University)

  • Akitsugu Yamamoto

    (Faculty of Bioscience, Nagahama Institute of Bio-Science and Technology)

  • Issei Komuro

    (Osaka University Graduate School of Medicine)

  • Kinya Otsu

    (Osaka University Graduate School of Medicine
    King’s College London, London SE5 9NU, UK)

Abstract

Mitochondrial DNA escaping from the autophagy pathway can trigger inflammation through Toll-like receptor (TLR) 9, leading to abnormalities in cardiac structure and function, and increased mortality.

Suggested Citation

  • Takafumi Oka & Shungo Hikoso & Osamu Yamaguchi & Manabu Taneike & Toshihiro Takeda & Takahito Tamai & Jota Oyabu & Tomokazu Murakawa & Hiroyuki Nakayama & Kazuhiko Nishida & Shizuo Akira & Akitsugu Ya, 2012. "Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure," Nature, Nature, vol. 485(7397), pages 251-255, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7397:d:10.1038_nature10992
    DOI: 10.1038/nature10992
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    Citations

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    Cited by:

    1. Ryuta Sugihara & Manabu Taneike & Tomokazu Murakawa & Takahito Tamai & Hiromichi Ueda & Rika Kitazume-Taneike & Takafumi Oka & Yasuhiro Akazawa & Hiroki Nishida & Kentaro Mine & Ayana Hioki & Jumpei O, 2023. "Lysophosphatidylserine induces necrosis in pressure overloaded male mouse hearts via G protein coupled receptor 34," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Naijun Miao & Zhuning Wang & Qinlan Wang & Hongyan Xie & Ninghao Yang & Yanzhe Wang & Jin Wang & Haixia Kang & Wenjuan Bai & Yuanyuan Wang & Rui He & Kepeng Yan & Yang Wang & Qiongyi Hu & Zhaoyuan Liu, 2023. "Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    3. Yinsheng Wu & Lixu Tang & Han Huang & Qi Yu & Bicheng Hu & Gang Wang & Feng Ge & Tailang Yin & Shanshan Li & Xilan Yu, 2023. "Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    4. Zoë P. Van Acker & Anika Perdok & Ruben Hellemans & Katherine North & Inge Vorsters & Cedric Cappel & Jonas Dehairs & Johannes V. Swinnen & Ragna Sannerud & Marine Bretou & Markus Damme & Wim Annaert, 2023. "Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    5. Toshiyuki Ko & Seitaro Nomura & Shintaro Yamada & Kanna Fujita & Takanori Fujita & Masahiro Satoh & Chio Oka & Manami Katoh & Masamichi Ito & Mikako Katagiri & Tatsuro Sassa & Bo Zhang & Satoshi Hatsu, 2022. "Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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