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Lysophosphatidylserine induces necrosis in pressure overloaded male mouse hearts via G protein coupled receptor 34

Author

Listed:
  • Ryuta Sugihara

    (Osaka University Graduate School of Medicine)

  • Manabu Taneike

    (Osaka University Graduate School of Medicine)

  • Tomokazu Murakawa

    (Osaka University Graduate School of Medicine)

  • Takahito Tamai

    (Osaka University Graduate School of Medicine)

  • Hiromichi Ueda

    (Osaka University Graduate School of Medicine
    Osaka University Graduate School of Medicine)

  • Rika Kitazume-Taneike

    (Osaka University Graduate School of Medicine)

  • Takafumi Oka

    (Osaka University Graduate School of Medicine)

  • Yasuhiro Akazawa

    (Osaka University Graduate School of Medicine)

  • Hiroki Nishida

    (Osaka University Graduate School of Medicine)

  • Kentaro Mine

    (Osaka University Graduate School of Medicine)

  • Ayana Hioki

    (Osaka University Graduate School of Medicine)

  • Jumpei Omi

    (The University of Tokyo)

  • Shigemiki Omiya

    (King’s College London British Heart Foundation Centre of Excellence
    National Cerebral and Cardiovascular Center)

  • Junken Aoki

    (The University of Tokyo)

  • Kazutaka Ikeda

    (RIKEN Center for Integrative Medical Sciences (IMS)
    Yokohama-City University)

  • Kazuhiko Nishida

    (King’s College London British Heart Foundation Centre of Excellence)

  • Makoto Arita

    (RIKEN Center for Integrative Medical Sciences (IMS)
    Yokohama-City University
    Keio University Faculty of Pharmacy)

  • Osamu Yamaguchi

    (Ehime University Graduate School of Medicine)

  • Yasushi Sakata

    (Osaka University Graduate School of Medicine)

  • Kinya Otsu

    (King’s College London British Heart Foundation Centre of Excellence
    National Cerebral and Cardiovascular Center)

Abstract

Heart failure is a leading cause of mortality in developed countries. Cell death is a key player in the development of heart failure. Calcium-independent phospholipase A2β (iPLA2β) produces lipid mediators by catalyzing lipids and induces nuclear shrinkage in caspase-independent cell death. Here, we show that lysophosphatidylserine generated by iPLA2β induces necrotic cardiomyocyte death, as well as contractile dysfunction mediated through its receptor, G protein-coupled receptor 34 (GPR34). Cardiomyocyte-specific iPLA2β-deficient male mice were subjected to pressure overload. While control mice showed left ventricular systolic dysfunction with necrotic cardiomyocyte death, iPLA2β-deficient mice preserved cardiac function. Lipidomic analysis revealed a reduction of 18:0 lysophosphatidylserine in iPLA2β-deficient hearts. Knockdown of Gpr34 attenuated 18:0 lysophosphatidylserine-induced necrosis in neonatal male rat cardiomyocytes, while the ablation of Gpr34 in male mice reduced the development of pressure overload-induced cardiac remodeling. Thus, the iPLA2β—lysophosphatidylserine—GPR34—necrosis signaling axis plays a detrimental role in the heart in response to pressure overload.

Suggested Citation

  • Ryuta Sugihara & Manabu Taneike & Tomokazu Murakawa & Takahito Tamai & Hiromichi Ueda & Rika Kitazume-Taneike & Takafumi Oka & Yasuhiro Akazawa & Hiroki Nishida & Kentaro Mine & Ayana Hioki & Jumpei O, 2023. "Lysophosphatidylserine induces necrosis in pressure overloaded male mouse hearts via G protein coupled receptor 34," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40201-4
    DOI: 10.1038/s41467-023-40201-4
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    References listed on IDEAS

    as
    1. Takafumi Oka & Shungo Hikoso & Osamu Yamaguchi & Manabu Taneike & Toshihiro Takeda & Takahito Tamai & Jota Oyabu & Tomokazu Murakawa & Hiroyuki Nakayama & Kazuhiko Nishida & Shizuo Akira & Akitsugu Ya, 2012. "Correction: Corrigendum: Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure," Nature, Nature, vol. 490(7419), pages 292-292, October.
    2. Takafumi Oka & Shungo Hikoso & Osamu Yamaguchi & Manabu Taneike & Toshihiro Takeda & Takahito Tamai & Jota Oyabu & Tomokazu Murakawa & Hiroyuki Nakayama & Kazuhiko Nishida & Shizuo Akira & Akitsugu Ya, 2012. "Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure," Nature, Nature, vol. 485(7397), pages 251-255, May.
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