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Stereospecific binding of a disordered peptide segment mediates BK channel inactivation

Author

Listed:
  • Vivian Gonzalez-Perez

    (Washington University School of Medicine)

  • Xu-Hui Zeng

    (Washington University School of Medicine
    Present address: Institute of Life Science, Nanchang University, 999 Xuefu Road, Honggu District, Nanchang 330031, China.)

  • Katie Henzler-Wildman

    (Washington University School of Medicine)

  • Christopher J. Lingle

    (Washington University School of Medicine)

Abstract

Two-step BK channel inactivation mediated by an intrinsically disordered BK β-subunit peptide involves a stereospecific binding interaction that precedes blockade.

Suggested Citation

  • Vivian Gonzalez-Perez & Xu-Hui Zeng & Katie Henzler-Wildman & Christopher J. Lingle, 2012. "Stereospecific binding of a disordered peptide segment mediates BK channel inactivation," Nature, Nature, vol. 485(7396), pages 133-136, May.
    • Handle: RePEc:nat:nature:v:485:y:2012:i:7396:d:10.1038_nature10994
    DOI: 10.1038/nature10994
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    Cited by:

    1. Paul J Pfaffinger, 2013. "A Conserved Pre-Block Interaction Motif Regulates Potassium Channel Activation and N-Type Inactivation," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-14, November.

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